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Association of an IRF3 putative functional uORF variant with resistance to Brucella infection: A candidate gene based analysis of InDel polymorphisms in goats
Rossi, Ursula; Hasenauer, Flavia Carolina; Caffaro, María Eugenia; Raschia, Maria Agustina; Maurizio, Estefania; Cortez, Hector Sergio; Neumann, Roberto Daniel; Poli, Mario Andres; Rossetti, Carlos Alberto (Elsevier, 2019-03)Brucellosis is an important zoonotic disease caused by infection with Brucella spp. It generates major economic losses in livestock production worldwide. Goats are the principal hosts of B. melitensis, the main infection ... -
Association of TNF rs668920841 and INRA111 polymorphisms with caprine brucellosis: A case-control study of candidate genes involved in innate immunity
Hasenauer, Flavia Carolina; Rossi, Ursula; Caffaro, María Eugenia; Raschia, Maria Agustina; Maurizio, Estefanía; Poli, Mario Andres; Rossetti, Carlos Alberto (Elsevier, 2020-11)Caprine brucellosis is an infectious, contagious zoonotic disease caused by Brucella melitensis. Multiple factors, including host genetics, can influence the outcome of the exposure to Brucella; and it is expected that ... -
Caprine brucellosis : a historically neglected disease with significant impact on public health
Rossetti, Carlos Alberto; Arenas-Gamboa, Angela M.; Maurizio, Estefania (2017-08)Caprine brucellosis is a chronic infectious disease caused by the gram-negative cocci-bacillus Brucella melitensis. Middle- to late-term abortion, stillbirths, and the delivery of weak offspring are the characteristic ... -
Characterization of innate immune response to Brucella melitensis infection in goats with permissive or restrictive phenotype for Brucella intramacrophagic growth
Maurizio, Estefanía; Trangoni, Marcos David; Rossi, Ursula; Dunleavy, Mariana Victoria; Colato, Claudio; Rossetti, Carlos Alberto (Elsevier, 2021-04)Caprine brucellosis is a chronic, world-wide distributed disease which causes reproductive failure in goats and Brucella melitensis, its causative agent, bears a great zoonotic potential. There is evidence suggesting that ... -
Comparative review of brucellosis in small domestic ruminants
Rossetti, Carlos Alberto; Maurizio, Estefanía; Rossi, Ursula Amaranta (Frontiers Media, 2022-05)Brucella melitensis and Brucella ovis are the primary etiological agents of brucellosis in small domestic ruminants. B. melitensis was first isolated in 1887 by David Bruce in Malta Island from spleens of four soldiers, ... -
Cytokine expression profile of B. melitensis-infected goat monocyte-derived macrophages
Maurizio, Estefanía; Rossi, Ursula Amaranta; Trangoni, Marcos David; Rossetti, Carlos Alberto (Elsevier, 2023-05)Brucella parasitize the macrophage where is able to replicate and modulate the immune response in order to establish a chronic infection. The most adequate response to control and eliminate Brucella infection is a type 1 ... -
Evaluation of the safety profile of the vaccine candidate Brucella melitensis 16MDvjbR strain in goats
Castaño Zubieta, Mirta Raquel; Rossetti, Carlos Alberto; Garcia-Gonzalez, Daniel G.; Maurizio, Estefanía; Hensel, Martha E.; Rice-Ficht, Allison C.; Ficht, Thomas A.; Arenas-Gamboa, Angela M. (Elsevier, 2021-01)Small ruminant brucellosis is caused by the Gram negative cocci-bacillus Brucella (B.) melitensis, the most virulent Brucella species for humans. In goats and sheep, middle to late-term gestation abortion, stillbirths and ...