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A direct high-throughput in Cell-ELISA for measuring infectivity of cytopathic and non-cytopathic bovine viral diarrhoea virus strains applied to the assessment of antiviral activity
Quintana, Maria Eugenia; Barone, Lucas; Forlenza, María Belén; Trotta, Myrian Vanesa; Turco, Cecilia; Mansilla, Florencia Celeste; Cardoso, Nancy Patricia; Capozzo, Alejandra Victoria (Elsevier, 2018-07-19)Low-cost high-throughput methods applicable to any virus strain are required for screening antiviral compounds against multiple field strains. Colorimetric cell-viability assays are used for this purpose as long as the ... -
Alternatives for the serological assessment of foot-and-mouth disease vaccine immunity in buffaloes (Bubalus bubalis)
Sala, Juan Manuel; Trotta, Myrian Vanesa; Mansilla, Florencia Celeste; Perez Filgueira, Daniel Mariano; Caspe, Sergio Gaston; Capozzo, Alejandra (2018)Buffaloes are compulsory vaccinated against foot-and-mouth disease virus (FMDV) in many countries as part of the official control programmes. Serological testing aimed to indirectly assess herd immunity is currently performed ... -
Apicomplexan profilins in vaccine development applied to bovine neosporosis
Mansilla, Florencia Celeste; Capozzo, Alejandra (2017-12)Neospora caninum, an intracellular protozoan parasite from the phylum Apicomplexa, is the etiologic agent of neosporosis, a disease considered as a major cause of reproductive loss in cattle and neuromuscular disease in ... -
Bovine interferon lambda Is a potent antiviral against SARS-CoV-2 infection in vitro
Cardoso, Nancy; Mansilla, Florencia Celeste; Benedetti, Estefanía; Turco, Cecilia Soledad; Barone, Lucas Jose; Iserte, Javier Alonso; Soria, Ivana; Baumeister, Elsa; Capozzo, Alejandra (Frontiers Media, 2020-11)Interferon lambda (IFN-λ) is an antiviral naturally produced in response to viral infections, with activity on cells of epithelial origin and located in the mucosal surfaces. This localized activity results in reduced ... -
Chronic NOD2 stimulation by MDP confers protection against parthanatos through M2b macrophage polarization in RAW264.7 cells
Mansilla, Florencia Celeste; Miraglia, Maria Cruz; Maidana, Silvina Soledad; Randazzo, Cecilia Paola; Capozzo, Alejandra (Elsevier, 2024-09)Innate immune cells show enhanced responsiveness to secondary challenges after an initial non-related stimulation (Trained Innate Immunity, TII). Acute NOD2 activation by Muramyl-Dipeptide (MDP) promotes TII inducing the ... -
Development and validation of a novel ELISA for the detection of Neospora caninum antibodies in bovine sera
Mansilla, Florencia Celeste; Gual, Ignacio; Pereyra, Walter Rodrigo; Cardoso, Nancy Patricia; Turco, Cecilia; Capozzo, Alejandra Victoria (Annex Publishers, 2019-08-26)Neospora caninum is a world-wide distributed apicomplexan parasite, causative agent of bovine neosporosis, which is one of the major causes of reproductive losses in cattle affecting both dairy and beef industries. Several ... -
Efecto antiviral de la ivermectina sobre la infección por alfaherpesvirus bovino 1 en bovinos
Maidana, Silvina Soledad; Martinez, Norberto Claudio; Mansilla, Florencia Celeste; Donato, Antonella María; Wegrzyn, Leandro Iván; Romera, Sonia Alejandra (Universidad de Córdoba (Colombia), 2025-09)Objetivo. Las medidas convencionales de control de la rinotraqueítis causada por el BoAHV-1 (BoAHV-1, IBR), incluyen la vacunación y las medidas de higiene del ganado bovino. En este estudio, se evaluó un fármaco antiparasitario ... -
Enhanced infectivity of bovine viral diarrhoea virus (BVDV) in arginase-producing bovine monocyte-derived macrophages
Barone, Lucas Jose; Cardoso, Nancy; Mansilla, Florencia Celeste; Castillo, Mariangeles; Capozzo, Alejandra (Taylor & Francis, 2024)Macrophages are important cells of the innate immunity that play a major role in Bovine Viral Diarrhoea Virus (BVDV) pathogenesis. Macrophages are not a homogenous population; they exist in different phenotypes, typically ... -
Evaluation of serological response to foot-and-mouth disease vaccination in BLV infected cows
Puentes, Rodrigo; De Brun, Laureana; Algorta, Agustina; Da Silva, Valeria; Mansilla, Florencia Celeste; Sacco, Gustavo; Llambí, Silvia; Capozzo, Alejandra Victoria (2016)Bovine Leukemia Virus (BLV) produces disorders on the immune system in naturally infected animals, which may counteract the development of immunity after vaccination. The aim of this study was to investigate whether healthy ... -
Evidence of reduced vertical transmission of Neospora caninum associated with higher IgG1 than IgG2 serum levels and presence of IFN-γ in nonaborting chronically infected cattle under natural condition
Pereyra, Walter Rodrigo; Mansilla, Florencia Celeste; Petersen, Marcos Iván; Suarez, Victor Humberto; Capozzo, Alejandra Victoria (Elsevier, 2019-02)Neospora caninum infection of cattle can be vertically transmitted, resulting in abortion or birth of infected calves. Vertical transmission occurs both in acutely or chronically infected cattle. There is little information ... -
Fasciola hepatica infection modifies IgG1 specific immune response to foot-and-mouth disease virus induced by vaccination
Costa, Monique; Mansilla, Florencia Celeste; Sala, Juan Manuel; Saravia, Anderson; Ubios, Diego; Lores, Pablo; Capozzo, Alejandra; Freire, Teresa (Elsevier, 2024-01)Fasciola hepatica, a worldwide distributed helminth, has a robust immunoregulatory effect in the host, increasing the susceptibility to secondary infections. Foot and mouth disease (FMD) is a highly contagious acute vesicular ... -
Fusion of foreign T-cell epitopes and addition of TLR agonists enhance immunity against Neospora caninum profilin in cattle
Mansilla, Florencia Celeste; Quintana, Maria Eugenia; Cardoso, Nancy; Capozzo, Alejandra (2016)We demonstrated recently that immunization with recombinant Neospora caninum profilin (rNcPRO) induces limited protection and a regulatory T-cell response in mice. The aim of this study was to evaluate the immune response ... -
Immune cells transferred by colostrum do not influence the immune responses to foot-and-mouth disease primary vaccination
Bucafusco, Danilo; Pereyra, Walter Rodrigo; Mansilla, Florencia Celeste; Malacari, Darío Amilcar; Juncos, María S.; Di Giacomo, Sebastián; Ayude, Andrea Fabiana; Perez Filgueira, Daniel Mariano; Capozzo, Alejandra Victoria (Elsevier, 2019-09)Little is known about the influence of maternal antibodies and immune cells transferred through colostrum on the immune responses of calves to the currently used foot-and-mouth disease (FMD) vaccines. Here we evaluated the ... -
Immunization with Neospora caninum profilin induces limited protection and a regulatory T-cell response in mice
Mansilla, Florencia Celeste; Quintana, Maria Eugenia; Langellotti, Cecilia Ana; Wilda, Maximiliano; Martinez, Andrea; Fonzo, Adriana; Moore, Prando Dadin; Cardoso, Nancy; Capozzo, Alejandra (2016)Profilins are actin-binding proteins that regulate the polymerization of actin filaments. In apicomplexan parasites, they are essential for invasion. Profilins also trigger the immune response of the host by activating ... -
Impact of genetic ancestry on the distribution of interferon-λ4 RS12979860 polymorphism in a global population of Buenos Aires, Argentina = Impacto de la ancestría genética en la distribución del polimorfismo de interferón-λ4 RS12979860 en una población global de Buenos Aires, Argentina
Mansilla, Florencia Celeste; Avena, Sergio; Dejean, Cristina; Turco, Cecilia Soledad; Capozzo, Alejandra (Sociedad Argentina de Genética, 2022-12)Human interferon-λ4 is a cytokine involved in early stages of antiviral responses. Strikingly, some allelic variants with diminished antiviral activity reduce the susceptibility to viral infections, thus they would have ... -
In-vivo activity of IFN-λ and IFN-α against bovine-viral-diarrhea virus in a mouse model
Quintana, Maria Eugenia; Barone, Lucas Jose; Trotta, Myrian Vanesa; Turco, Cecilia Soledad; Mansilla, Florencia Celeste; Capozzo, Alejandra; Cardoso, Nancy (Frontiers Media, 2020-02)Bovine-viral-diarrhea virus (BVDV) can cause significant economic losses in livestock. The disease is controlled with vaccination and bovines are susceptible until vaccine immunity develops and may remain vulnerable if a ... -
Interferon lambda protects cattle against bovine viral diarrhea virus infection
Quintana, Maria Eugenia; Cardoso, Nancy; Pereyra, Walter Rodrigo; Barone, Lucas Jose; Barrionuevo, Florencia Mariel; Mansilla, Florencia Celeste; Turco, Cecilia Soledad; Capozzo, Alejandra (Elsevier, 2020-12)Interferon lambda (IFN-λ) plays an important role in inducing an antiviral state in mucosal surfaces and has been used as an effective biotherapeutic against several viral diseases. Here we performed a proof of concept ... -
Kinetics of foot-and-mouth disease vaccine-induced antibody responses in buffaloes (Bubalus bubalis): avidity ELISA as an alternative to the virus neutralization test
Sala, Juan Manuel; Mansilla, Florencia Celeste; Miraglia, Maria Cruz; Caspe, Sergio Gaston; Perez Filgueira, Daniel Mariano; Capozzo, Alejandra (Frontiers Media, 2023-11)The role of water buffaloes in foot-and-mouth disease (FMD) epidemiology as one of the major hosts of the virus that can develop persistent asymptomatic infection highlights the importance of sustaining surveillance on the ... -
Pre-existing anti-inflammatory immune conditions influence early antibody avidity and isotype profile following Comirnaty® vaccination in mice
Castillo, Mariangeles; Miraglia, Maria Cruz; Mansilla, Florencia Celeste; Randazzo, Cecilia Paola; Bentancor, Leticia Veronica; Freire, Teresa; Capozzo, Alejandra (MDPI, 2025-07)Background/Objectives: Vaccine immunogenicity is often suboptimal in vulnerable populations such as the elderly, infants, and individuals in low- and middle-income countries. One contributing factor may be pre-existing ... -
Prevalencia sérica de Neospora caninum y factores de riesgo asociados a su transmisión en tambos de la provincia de Salta, Argentina
Pereyra, Walter Rodrigo; Suarez, Victor Humberto; Cardoso, Nancy; Gual, Ignacio; Martinez, Gabriela Marcela; Capozzo, Alejandra; Mansilla, Florencia Celeste (Elsevier, 2020-09-11)El objetivo de este trabajo fue conocer la seroprevalencia de Neospora caninum en los bovinos de los tambos del Valle del Lerma (Salta, Argentina) y los factores de riesgo asociados a la transmisión de este parásito en ...