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A DNA vaccine formulated with chemical adjuvant provides partial protection against bovine herpes virus infection in cattle
Quattrocchi, Valeria; Soria, Ivana; Langellotti, Cecilia Ana; Gnazzo, Victoria; Gammella, Mariela; Moore, Prando Dadin; Zamorano, Patricia Ines (2017-01-25)Bovine herpesvirus-1 (BoHV-1) is the causative agent of bovine infectious rhinotracheitis, an important disease worldwide. Although conventional BoHV-1 vaccines, including those based on the use of modified live virus and ... -
A new cage-like particle adjuvant enhances protection of foot-and-mouth disease vaccine
Bidart, Juan Esteban; Kornuta, Claudia Alejandra; Gammella, Mariela; Gnazzo, Victoria; Soria, Ivana; Langellotti, Cecilia Ana; Mongini, Claudia; Galarza, Roxana Ivon; Calvinho, Luis Fernando; Lupi, Giuliana; Quattrocchi, Valeria; Marcipar, Ivan; Zamorano, Patricia Ines (Frontiers Media, 2020-07)Foot-and-Mouth Disease (FMD) is an acute viral disease that causes important economy losses. Vaccines with new low-cost adjuvants that stimulate protective immune responses are needed and can be assayed in a mouse model ... -
A plasmid encoding the extracellular domain of CD40 ligand and MontanideTM GEL01 as adjuvants enhance the immunogenicity and the protection induced by a DNA vaccine against BoHV-1
Kornuta, Claudia Alejandra; Langellotti, Cecilia Ana; Bidart, , Juan Esteban; Soria, Ivana; Quattrocchi, Valeria; Gammella, Mariela; Cheuquepan Valenzuela, Felipe; Mignaqui, Ana Clara; Ferraris, Sergio; Charleston, Bryan; Hecker, Yanina; Moore, Prando Dadin; Zamorano, Patricia Ines (Elsevier, 2021-02)DNA vaccines are capable of inducing humoral and cellular immunity, and are important to control bovine herpesvirus 1 (BoHV-1), an agent of the bovine respiratory disease complex. In previous work, a DNA plasmid that encodes ... -
An improved DNA vaccine against bovine herpesvirus-1 using CD40L and a chemical adjuvant induces specific cytotoxicity in mici
Langellotti, Cecilia Ana; Gammella, Mariela; Soria, Ivana; Bellusci, Carolina; Quattrocchi, Valeria; Vermeulen, Elba Monica; Mongini, Claudia; Zamorano, Patricia Ines (Mary Ann Liebert, 2021-03)Bovine herpesvirus-1 (BoHV-1) uses many mechanisms to elude the immune system; one of them is spreading intracellularly, even in the presence of specific antiviral antibodies. Cytotoxic T lymphocytes (CTLs) are necessary ... -
Bovine dendritic cell activation, T cell proliferation and antibody responses to foot-and-mouth disease, is similar with inactivated virus and virus like particles
Quattrocchi, Valeria; Bidart, Juan Esteban; Mignaqui, Ana Clara; Ruiz, Vanesa; Ferella, Alejandra; Langellotti, Cecilia Ana; Gammella, Mariela; Ferraris, Sergio; Carrillo, Jorge Ernesto; Wigdorovitz, Andres; Durocher, Yves; Cardillo, Sabrina Beatriz; Charleston, Bryan; Zamorano, Patricia Ines (Frontiers Media, 2020-09)Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals that causes severe economic losses in the livestock industry. Currently available vaccines are based on the inactivated FMD virus (FMDV). ... -
Dendrimeric peptides can confer protection against foot-and-mouth disease virus in cattle
Soria, Ivana; Quattrocchi, Valeria; Langellotti, Cecilia Ana; Gammella, Mariela; Di Giacomo, Sebastián; Garcia de la Torre, Beatriz; Andreu, David; Montoya, Maria; Sobrino, Francisco; Blanco, Esther; Zamorano, Patricia Ines (2017-09)Foot-and-mouth disease virus (FMDV) causes a highly contagious disease in cloven-hoofed animals. A synthetic vaccine candidate consisting of dendrimeric peptides harbouring two copies of a B-epitope [VP1(136–154)] linked ... -
Dendritic cell targeting in cultured fish in Argentina for vaccine development
Ghersa, Federica; Soria, Ivana; Quattrocchi, Valeria; Gammella, Mariela; Langellotti, Cecilia Ana; Zamorano, Patricia Ines; Rauque, Carlos Alejandro; Pappalardo, Juan Sebastián (Edición del Autor, 2019)In Argentina two main species present an important economic value, these are Pacú (Piaractus mesopotamicus, Pm) and Rainbow Trout (Oncorhynchus mykiss, Om). Due to stress and changing environmental conditions cultured fish ... -
Evaluation of total white blood cell count as a marker for proviral load of bovine leukemia virus in dairy cattle from herds with a high seroprevalence of antibodies against bovine leukemia virus
Alvarez, Irene; Gutierrez, Gerónimo; Gammella, Mariela; Martínez, Cecilia; Politzki, Romina Paula; González, Cintia Beatríz; Caviglia, Luciana; Carignano, Hugo; Fondevila, Norberto Antonio; Poli, Mario Andres; Trono, Karina Gabriela (2013-05)Objective—To determine the reference interval for WBC counts in Holstein dairy cows from herds with high seroprevalence for anti–bovine leukemia virus (BLV) antibodies, analyze the correlation of total WBC counts and blood ... -
FMD empty capsids combined with the immunostant particle adjuvant -ISPA or ISA206 induce protective immunity against foot and mouth disease virus
Bidart, Juan Esteban; Mignaqui, Ana Clara; Kornuta, Claudia Alejandra; Lupi, Giuliana; Gammella, Mariela; Soria, Ivana; Galarza, Roxana Ivon; Ferella, Alejandra; Cardillo, Sabrina Beatriz; Langellotti, Cecilia Ana; Quattrocchi, Valeria; Durocher, Yves; Wigdorovitz, Andres; Marcipar, Ivan; Zamorano, Patricia Ines (Elsevier, 2021-05)Foot and Mouth Disease Virus (FMDV) causes economy losses and is controlled by vaccination in many countries. Vaccine formulations based on empty capsids or Virus-Like Particles (VLPs) have the advantage of avoiding the ... -
MANα1-2MAN decorated liposomes enhance the immunogenicity induced by a DNA vaccine against BoHV-1
Kornuta, Claudia Alejandra; Bidart, , Juan Esteban; Soria, Ivana; Gammella, Mariela; Quattrocchi, Valeria; Pappalardo, Juan Sebastián; Salmaso, Stefano; Torchilin, Vladimir P.; Cheuquepan Valenzuel, Felipe Andres; Hecker, Yanina; Moore, Dadin P.; Zamorano, Patricia Ines; Langellotti, Cecilia Ana (Wiley, 2021-03)New technologies in the field of vaccinology arise as a necessity for the treatment and control of many diseases. Whole virus inactivated vaccines and modified live virus ones used against Bovine Herpesvirus‐1 (BoHV‐1) ... -
TLR activation, immune response and viral protection elicited in cattle by a commercial vaccine against Bovine Herpesvirus-1
Kornuta, Claudia Alejandra; Cheuquepan Valenzuel, Felipe Andres; Bidart, , Juan Esteban; Soria, Ivana; Gammella, Mariela; Quattrocchi, Valeria; Hecker, Yanina; Moore, Prando Dadin; Romera, Sonia Alejandra; Marin, Maia Solange; Zamorano, Patricia Ines; Langellotti, Cecilia Ana (Elsevier, 2022-01)The innate and acquired immune response induced by a commercial inactivated vaccine against Bovine Herpesvirus-1 (BoHV-1) and protection conferred against the virus were analyzed in cattle. Vaccination induced high levels ...