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Mostrando ítems 1-6 de 6

    • A DIVA-compatible Mycobacterium bovis triple mutant vaccine confers protection against bovine tuberculosis in mouse model 

      Blanco, Federico Carlos; Onnainty, Renée; Marini, María Rocío; Klepp, Laura Ines; Rocha, Rosana Valeria; Villafañe, Luciana María; Vazquez, Cristina Lourdes; Canal, Ana; Granero, Gladys; Bigi, Fabiana (Elsevier, 2025-09)
      Bovine tuberculosis (bTB) is a pulmonary infectious disease caused by Mycobacterium bovis, affecting cattle and a wide range of mammals, including humans. Despite its significant impact on global livestock production, ...

    • Characterization of the two component regulatory system PhoPR in Mycobacterium bovis 

      Garcia, Elizabeth Andrea; Blanco, Federico Carlos; Bigi, María Mercedes; Vazquez, Cristina Lourdes; Forrellad, Marina Andrea; Rocha, Rosana Valeria; Golby, Paul; Soria, Marcelo Abel; Bigi, Fabiana (Elsevier, 2018-08)
      Mycobacterium bovis is the causative agent of bovine tuberculosis and is a member of Mycobacterium tuberculosis complex, which causes tuberculosis in a number of mammals including humans. Previous studies have shown that ...

    • Field trial with vaccine candidates against bovine tuberculosis among likely infected cattle in a natural transmission setting 

      Ferrara Muñiz, Ximena; Garcia, Elizabeth Andrea; Blanco, Federico Carlos; Garbaccio, Sergio Gabriel; Garro, Carlos Javier; Zumarraga, Martin Jose; Dellagostin, Odir A.; Trangoni, Marcos David; Marfil, Maria Jimena; Bianco, María Veronica; Abdala, Alejandro Ariel; Revelli, Javier; Bergamasco, Maria; Soutullo, Adriana; Marini, M. Rocío; Rocha, Rosana Valeria; Sánchez, Amorina; Bigi, Fabiana; Canal, Ana María; Eirin, Maria Emilia; Cataldi, Angel Adrian (MDPI, 2024-10)
      Background/Objectives: Vaccines may improve the control and eradication of bovine tuberculosis. However, the evaluation of experimental candidates requires the assessment of the protection, excretion, transmission and ...

    • Mycobacterium bovis mutant in the virulence factors PhoP, ESAT-6 and CFP-10 persisted in mouse organs after a year post-vaccination 

      Blanco, Federico Carlos; Vazquez, Cristina Lourdes; Garcia, Elizabeth Andrea; Rocha, Rosana Valeria; Klepp, Laura Ines; Bigi, Fabiana (Elsevier, 2024-12)
      A vaccine for bovine tuberculosis is urgently needed. The BCG vaccine (the Bacille Calmette-Guérin), currently the only licensed vaccine for tuberculosis in humans, offers variable protection in cattle. However, BCG is a ...

    • Rv2617c and P36 are virulence factors of pathogenic mycobacteria involved in resistance to oxidative stress 

      Forrellad, Marina Andrea; Vazquez, Cristina Lourdes; Blanco, Federico Carlos; Klepp, Laura Ines; Garcia, Elizabeth Andrea; Rocha, Rosana Valeria; Villafañe, Luciana Maria; Bigi, María Mercedes; Gutierrez, Maximiliano Gabriel; Bigi, Fabiana (Taylor & Francis, 2019-12)
      In this study, we characterized the role of Rv2617c in the virulence of Mycobacterium tuberculosis. Rv2617c is a protein of unknown function unique to M. tuberculosis complex (MTC) and Mycobacterium leprae. In vitro, this ...

    • Study of the in vivo role of Mce2R, the transcriptional regulator of mce2 operon in Mycobacterium tuberculosis 

      Forrellad, Marina Andrea; Bianco, María Veronica; Blanco, Federico Carlos; Nuñez, Javier; Klepp, Laura Ines; Vazquez, Cristina Lourdes; Santangelo, María De La Paz; Rocha, Rosana Valeria; Soria, Marcelo; Golby, Paul; Gutierrez, Maximiliano Gabriel; Bigi, Fabiana (BMC, 2013-09)
      Background: Tuberculosis is one of the leading causes of mortality throughout the world. Mycobacterium tuberculosis, the agent of human tuberculosis, has developed strategies involving proteins and other compounds called ...