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Assessment on different vaccine formulation parameters in the protection against heterologous challenge with FMDV in cattle
Di Giacomo, Sebastián; Bucafusco, Danilo; Schammas, Juan Manuel; Pega, Juan Franco; Miraglia, Maria Cruz; Barrionuevo, Florencia Mabel; Capozzo, Alejandra; Perez Filgueira, Daniel Mariano (MDPI, 2022-08)Foot-and-mouth disease (FMD) remains one of the major threats to animal health worldwide. Its causative agent, the FMD virus (FMDV), affects cloven-hoofed animals, including farm animals and wildlife species, inflicting ... -
Chronic NOD2 stimulation by MDP confers protection against parthanatos through M2b macrophage polarization in RAW264.7 cells
Mansilla, Florencia Celeste; Miraglia, Maria Cruz; Maidana, Silvina Soledad; Randazzo, Cecilia Paola; Capozzo, Alejandra (Elsevier, 2024-09)Innate immune cells show enhanced responsiveness to secondary challenges after an initial non-related stimulation (Trained Innate Immunity, TII). Acute NOD2 activation by Muramyl-Dipeptide (MDP) promotes TII inducing the ... -
Field Evidence of Fasciola hepatica-Mediated Modulation of Antibody Responses to Foot-and-Mouth Disease Vaccination in Buffaloes
Sala, Juan Manuel; Wilda, Maximiliano; Miraglia, Maria Cruz; Castillo, Mariangeles; Perez Filgueira, Daniel Mariano; Freire, Teresa; Capozzo, Alejandra (MDPI, 2026-01)Background: Fasciola hepatica (F. hepatica) infection reduces antibody avidity to foot-and-mouth disease virus (FMDV) vaccination in cattle despite preserved total antibody levels. However, its effect on vaccine-induced ... -
Immune mediators of pathology in neurobrucellosis: from blood to central nervous system
Rodriguez, Ana María; Delpino, María Victoria; Miraglia, Maria Cruz; Giambartolomei, Guillermo Hernán (Elsevier, 2019-07)Neurobrucellosis, which is the most morbid form of brucellosis disease, presents with inflammatory signs and symptoms. Recent experimental evidence clearly indicates that deregulation of astrocytes and microglia caused by ... -
Impact of different foot and mouth disease vaccine schemes in cross-neutralization against heterologous serotype O strains in cattle
Miraglia, Maria Cruz; Barrios-Benito, Melanie; Galdo Novo, Sabrina; Bucafusco, Danilo; Taffarel, Ana; Capozzo, Alejandra; Borca, Manuel Victor; Perez Filgueira, Daniel Mariano (MDPI, 2024-11)The high antigenic variability of the foot-and-mouth disease virus (FMDV) represents a challenge for developing prophylactic strategies, stressing the need for research into vaccines offering broad protection against a ... -
Kinetics of foot-and-mouth disease vaccine-induced antibody responses in buffaloes (Bubalus bubalis): avidity ELISA as an alternative to the virus neutralization test
Sala, Juan Manuel; Mansilla, Florencia Celeste; Miraglia, Maria Cruz; Caspe, Sergio Gaston; Perez Filgueira, Daniel Mariano; Capozzo, Alejandra (Frontiers Media, 2023-11)The role of water buffaloes in foot-and-mouth disease (FMD) epidemiology as one of the major hosts of the virus that can develop persistent asymptomatic infection highlights the importance of sustaining surveillance on the ... -
Pre-existing anti-inflammatory immune conditions influence early antibody avidity and isotype profile following Comirnaty® vaccination in mice
Castillo, Mariangeles; Miraglia, Maria Cruz; Mansilla, Florencia Celeste; Randazzo, Cecilia Paola; Bentancor, Leticia Veronica; Freire, Teresa; Capozzo, Alejandra (MDPI, 2025-07)Background/Objectives: Vaccine immunogenicity is often suboptimal in vulnerable populations such as the elderly, infants, and individuals in low- and middle-income countries. One contributing factor may be pre-existing ... -
The role of viral particle integrity in the serological assessment of foot-and-mouth disease virus vaccine-induced immunity in swine
Mansilla, Florencia Celeste; Turco, Cecilia Soledad; Miraglia, Maria Cruz; Bessone, Fernando Aníbal; Franco, Raul Enrique; Perez Filgueira, Daniel Mariano; Sala, Juan Manuel; Capozzo, Alejandra (Plos One, 2020-05)The efficacy of foot-and-mouth disease virus (FMDV) inactivated vaccines is mainly dependent on the integrity of the whole (146S) viral particles. If the intact capsids disassemble to 12S subunits, antibodies against ...