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A novel association of BoLA DRB3 alleles in BLV infected cattle with different proviral loads
Nieto Farias, María Victoria; Caffaro, María Eugenia; Lendez, Pamela Anahí; Passucci, Juan; Poli, Mario Andres; Ceriani, María Carolina; Dolcini, Guillermina Laura (2017)Bovine leukemia virus (BLV) is associated with the most common neoplastic disease of cattle. BLV has a silent dissemination in the herd due to infected cell exchange, thus the concentration of BLV-infected cells in blood ... -
Association of an IRF3 putative functional uORF variant with resistance to Brucella infection: A candidate gene based analysis of InDel polymorphisms in goats
Rossi, Ursula; Hasenauer, Flavia Carolina; Caffaro, María Eugenia; Raschia, Maria Agustina; Maurizio, Estefania; Cortez, Hector Sergio; Neumann, Roberto Daniel; Poli, Mario Andres; Rossetti, Carlos Alberto (Elsevier, 2019-03)Brucellosis is an important zoonotic disease caused by infection with Brucella spp. It generates major economic losses in livestock production worldwide. Goats are the principal hosts of B. melitensis, the main infection ... -
Association of TNF rs668920841 and INRA111 polymorphisms with caprine brucellosis: A case-control study of candidate genes involved in innate immunity
Hasenauer, Flavia Carolina; Rossi, Ursula; Caffaro, María Eugenia; Raschia, Maria Agustina; Maurizio, Estefanía; Poli, Mario Andres; Rossetti, Carlos Alberto (Elsevier, 2020-11)Caprine brucellosis is an infectious, contagious zoonotic disease caused by Brucella melitensis. Multiple factors, including host genetics, can influence the outcome of the exposure to Brucella; and it is expected that ... -
BOLA-DRB3 gene polymorphisms influence bovine leukaemia virus infection levels in Holstein and Holstein × Jersey crossbreed dairy cattle
Carignano, Hugo Adrian; Beribe, Maria Jose; Caffaro, María Eugenia; Amadio, Ariel; Nani, Juan Pablo; Gutierrez, Gerónimo; Alvarez, Irene; Trono, Karina Gabriela; Miretti, Marcos Mateo; Poli, Mario Andres (2017-05)Bovine leukemia virus (BLV) infections, causing persistent lymphocytosis and lethal lymphosarcoma in cattle, have reached high endemicity on dairy farms. We observed extensive inter-individual variation in the level of ... -
Dataset from: “Frequencies of β-casein variants and their influence on genetic merit for production traits in Holstein cows [Conjunto de datos]
Caffaro, María Eugenia; Raschia, Maria Agustina; Maizon, Daniel Omar; Poli, Mario Andres (2024)The dataset consists of records from 2600 Holstein cows from three private farms in the central dairy area of Argentina with different breeding objectives and phenotypic records taken over different seasons, periods, and ... -
Deletion in KARLN intron 5 and predictive relationship with bovine tuberculosis and brucellosis infection phenotype
Rossi, Ursula Amaranta; Caffaro, María Eugenia; Raschia, Maria Agustina; Hasenauer, Flavia Carolina; Poli, Mario Andres; Rossetti, Carlos Alberto (Springer, 2023-06)Kalirin (gene: KALRN) is a Rho-GEF kinase linked to neurodegenerative diseases in humans. Unexpectedly, various polymorphisms in KALRN gene were previously associated with resistance to bacterial infections in ruminants. ... -
Desequilibrio de ligamiento en cromosomas con genes candidatos para calidad de lana en ovinos Corriedale
Cordoba, Marcela Elisabet; Raschia, Maria Agustina; Donzelli, María Valeria; Cetra, Bibiana Maria; Medus, Pablo Daniel; Bonelli, Rita; Caffaro, María Eugenia; Maizon, Daniel Omar; Poli, Mario Andres (INTA, 2024-11)Los enfoques moleculares para la selección permiten explotar el potencial genético de especies productoras de fibra, incorporando evaluaciones genómicas en programas de cría. Numerosos genes afectan la expresión de ... -
Diversity of the BoLA-DRB3 gene in cattle breeds from tropical and subtropical regions of Argentina
Valenzano, Magali Nicole; Caffaro, María Eugenia; Lia, Veronica Viviana; Poli, Mario Andres; Wilkowsky, Silvina Elizabeth (Springer, 2021-12)Bovine leukocyte antigens (BoLA) have been widely studied because of their primary function in the recognition of pathogens by the immune system. To date, however, the characterization of the BoLA-DRB3 gene in Latin American ... -
Estudio de variables biológicas ante un desafío artificial de L3 de H. contortus en dos majadas de ovinos Corriedale
Donzelli, María Valeria; Maizon, Daniel Omar; Cetra, Bibiana Maria; Medus, Pablo Daniel; Bonelli, Rita; Raschia, Maria Agustina; Caffaro, María Eugenia; Poli, Mario Andres (Asociación Argentina de Producción Animal, 2022-11)H. contortus es uno de los parásitos que ocasiona mayores problemas en regiones templadas, tropicales y subtropicales debido a pérdidas productivas y económicas. La utilización de drogas es fundamental para el control de ... -
Evaluation of polymorphisms at the 3´ UTR SLC11A1 gene microsatellites and their associations with the outcome of Brucella abortus infection in Bos taurus cattle
Hasenauer, Flavia Carolina; Caffaro, María Eugenia; Poli, Mario Andres; Rossetti, Carlos Alberto (Ediciones INTA, 2022-11)In ruminants, polymorphisms in microsatellites at 3´untranslated region (3´ UTR) of the SLC11A1 gene were associated with natural resistance to Brucella spp. and Mycobacterium spp. infection, but its relevance to prevent ... -
Exploring the association between polymorphisms at 3’UTR SLC11A1 gene microsatellites and resistance to tuberculosis: A case-control study in Bos taurus dairy cattle
Hasenauer, Flavia Carolina; Garbaccio, Sergio Gabriel; Caffaro, María Eugenia; Garro, Carlos Javier; Huertas, Pablo Sebastian; Poli, Mario Andres; Rossetti, Carlos Alberto (2018-04)Bovine tuberculosis is a contagious infectious disease that causes significant economic impact in dairy and meat farms throughout the world. Multiple factors, including host genome, determine the outcome of the infection. ... -
Expression-based analysis of genes related to single nucleotide polymorphism hits associated with bovine leukemia virus proviral load in Argentinean dairy cattle
Petersen, Marcos Iván; Carignano, Hugo Adrian; Suarez Archilla, Guillermo; Caffaro, María Eugenia; Alvarez, Irene; Miretti, Marcos Mateo; Trono, Karina Gabriela (Elsevier, 2021-02)In dairy cattle infected with bovine leukemia virus (BLV), the proviral load (PVL) level is directly related to the viral transmission from infected animals to their healthy herdmates. Two contrasting phenotypic groups can ... -
Frequencies of β-casein variants and their influence on genetic merit for production traits in Holstein cows
Caffaro, María Eugenia; Raschia, Maria Agustina; Maizon, Daniel Omar; Poli, Mario Andres (CSIRO Publishing, 2024-12)Context: Traits considered for selection are influenced by social, consumer, and breeder demands. In the past decades, there has been increasing global interest in producing milk free from the β-casein (CSN2) A1 allele ... -
Generalized glycogenosis in Brahman-derived breeds: diagnosis and prevalence in Argentina
Caffaro, María Eugenia; Raschia, Maria Agustina; Amadio, Ariel; Poli, Mario Andres (Springer, 2019-08)Generalized glycogenosis is a lethal autosomal recessive disease caused by a deficient activity of the acidic 1,4-α-glucosidase enzyme and characterized by an accumulation of glycogen within lysosomes. Three mutations in ... -
Genetic analysis of the 3′ untranslated region of the bovine SLC11A1 gene reveals novel polymorphisms
Hasenauer, Flavia Carolina; Caffaro, María Eugenia; Czibener, Cecilia; Comerci, Diego José; Poli, Mario Andres; Rossetti, Carlos Alberto (Springer, 2013-01)Polymorphisms in microsatellites at the 3′ untranslated region (3′UTR) of the SLC11A1 (solute carrier family 11 member A1) gene have been associated with natural resistance to Brucella abortus and Mycobacterium bovis ... -
Genetic resistance to gastrointestinal parasites in sheep
Poli, Mario Andres; Donzelli, María Valeria; Caffaro, María Eugenia; Raschia, Maria Agustina; Papaleo Mazzucco, Juliana; Rossi, Ursula Amaranta (CAB International, 2023-06)Gastrointestinal nematode (GIN) infection is the most common disease affecting sheep production systems throughout the world, causing significant productive and economic losses. The control of these parasites was traditionally ... -
Genotipificación de variantes de beta-caseína bovina mediante ACRSPCR- RFLP = Genotyping of bovine beta-casein variants by ACRS-PCR-RFLP
Caffaro, María Eugenia; Raschia, Maria Agustina; Poli, Mario Andres (Consejo de Rectores de Universidades Privadas, 2023-10)Las variantes de la beta-caseína bovina pueden clasificarse en dos grupos, tipo-A1 y tipo-A2, según el aminoácido que esté presente en la posición 67 de la proteína (His, tipo A1; Pro, tipo A2)1. En los últimos años se ha ... -
A haplotype at intron 8 of PTPRT gene is associated with resistance to Brucella infection in Argentinian creole goats
Rossi, Ursula; Hasenauer, Flavia Carolina; Caffaro, María Eugenia; Neumann, Roberto Daniel; Salatin, Antonio Omar; Poli, Mario Andres; Rossetti, Carlos Alberto (2017-08)Brucellosis is the leading zoonosis on a worldwide scale and constitutes a major public health threat in many regions of the world. Several molecular markers associated with natural resistance to intracellular bacterial ... -
Imputación de genotipos faltantes mediante algoritmos de machine learning = Imputation of missing genotypes using machine learning algorithms
Raschia, Maria Agustina; Rios, Pablo Javier; Cordoba, Marcela Elisabet; Caffaro, María Eugenia; Donzelli, María Valeria; Maizon, Daniel Omar; Demitrio, Daniel Arturo; Poli, Mario Andres (Sociedad Argentina de Informática e Investigación Operativa (SADIO), 2025-08)Resumen. La imputación o inferencia de genotipos faltantes utilizando correlaciones entre variantes obtenidas a partir de paneles de referencia puede ser llevada a cabo por programas específicos basados en la utilización ... -
An insertion in the caprine IRF3 gene affects macrophage response to B. melitensis infection
Rossi, Ursula Amaranta; Maurizio, Estefanía; Caffaro, María Eugenia; Poli, Mario Andres; Rossetti, Carlos Alberto (Universidad Nacional del Centro de la Provincia de Buenos Aires, 2023-08)Brucella melitensis is the etiological agent of brucellosis in goats and the main cause of human brucellosis. Interferons (IFNs) are important cytokines in the immune responses to intracellular pathogens and tumor cells. ...