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Browsing by Author "27268002109"

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    • Assessment of tuberculosis biomarkers in paratuberculosis-infected cattle 

      Klepp, Laura Ines; Colombatti Olivieri, Maria Alejandra; Moyano, Roberto Damian; Romano, Maria Isabel; Malovrh, Tadej; Ocepek, Matjaž; Blanco, Federico Carlos; Bigi, Fabiana (Sciendo, 2023-03)
      Introduction: Mycobacterium bovis and Mycobacterium avium subsp. paratuberculosis, respectively the causative agents of bovine tuberculosis (bTB) and bovine paratuberculosis (PTB), share a high number of antigenic proteins. ...

    • B cell and antibody responses in bovine tuberculosis 

      Klepp, Laura Ines; Blanco, Federico Carlos; Bigi, María Mercedes; Vazquez, Cristina Lourdes; Garcia, Elizabeth Andrea; Sabio Y Garcia, Julia Veronica; Bigi, Fabiana (MDPI, 2024-12)
      The development of vaccines and effective diagnostic methods for bovine tuberculosis requires an understanding of the immune response against its causative agent, Mycobacterium bovis. Although this disease is primarily ...

    • Development and evaluation of a low cost IgG ELISA test based in RBD protein for COVID-19 

      Villafañe, Luciana María; Gallo Vaulet, Maria Lucia; Viere, Florencia M.; Klepp, Laura Ines; Forrellad, Marina Andrea; Bigi, María Mercedes; Romano, Maria Isabel; Magistrelli, Giovanni; Rodríguez Fermepin, Marcelo; Bigi, Fabiana (Elsevier, 2022-01)
      Serology tests for SARS-CoV-2 have proven to be important tools to fight against the COVID-19 pandemic. These serological tests can be used in low-income and remote areas for patient contact tracing, epidemiologic studies ...

    • Does Mycobacterium bovis persist in cattle in a non-replicative latent state as Mycobacterium tuberculosis in human beings? 

      Sabio Y Garcia, Julia Veronica; Bigi, María Mercedes; Klepp, Laura Ines; Garcia, Elizabeth Andrea; Blanco, Federico Carlos; Bigi, Fabiana (Elsevier, 2020-08)
      Members of the Mycobacterium tuberculosis complex (MTBC) are responsible for tuberculosis in several mammals. In this complex, Mycobacterium tuberculosis and Mycobacterium bovis, which are closely related, show host ...

    • Dynamics of the in vitro growing of Mycobacterium bovis from the lungs of vaccinated and infected mice 

      Blanco, Federico Carlos; Klepp, Laura Ines; Vazquez, Cristina Lourdes; Bigi, Fabiana (Wolters Kluwer Medknow, 2025-06)
      Background: Bovine tuberculosis (bTB) is a disease primarily caused by Mycobacterium bovis. Currently, no commercial vaccines exist for controlling bTB, making the development of effective vaccine candidates and testing ...

    • ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosis 

      Blanco, Federico Carlos; Soria, Marcelo Abel; Klepp, Laura Ines; Bigi, Fabiana (Karger, 2017-12)
      Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses ...

    • Identification of bovine tuberculosis biomarkers to detect tuberculin skin test and IFNγ release assay false negative cattle 

      Klepp, Laura Ines; Eirin, Maria Emilia; Garbaccio, Sergio Gabriel; Soria, Marcelo Abel; Bigi, Fabiana; Blanco, Federico Carlos (Elsevier, 2019-02)
      Bovine tuberculosis (bTB) is an important animal and zoonotic disease, which causes severe economic losses. The main focus of this study was to assess the predictive power of previously identified biomarkers of bTB in ...

    • Long-term evaluation in BALBc mice of a triple mutant of Mycobacterium bovis and the Bacillus Calmette-Guérin as potential vaccines against bovine tuberculosis 

      Blanco, Federico Carlos; Marini, María Rocío; Klepp, Laura Ines; Vazquez, Cristina Lourdes; Garcia, Elizabeth Andrea; Bigi, María Mercedes; Canal, Ana María; Bigi, Fabiana (Elsevier, 2025-03)
      There is currently no commercial vaccine available against bovine tuberculosis (bTB). Mycobacterium bovis is the primary causative agent of bTB and is closely related to Mycobacterium tuberculosis, the pathogen responsible ...

    • M72 Fusion proteins in nanocapsules enhance BCG efficacy against bovine tuberculosis in a mouse model 

      Blanco, Federico Carlos; Onnainty, Renée; Marini, María Rocío; Klepp, Laura Ines; Garcia, Elizabeth Andrea; Vazquez, Cristina Lourdes; Canal, Ana María; Granero, Gladys; Bigi, Fabiana (MDPI, 2025-06)
      Mycobacterium bovis is the causative pathogen of bovine tuberculosis (bTB), a disease that affects cattle and other mammals, including humans. Currently, there is no efficient vaccine against bTB, underscoring the need for ...

    • Metabolic profile of mycobacterium smegmatis reveals Mce4 proteins are relevant for cell wall lipid homeostasis 

      Santangelo, María De La Paz; Heuberger, Adam; Blanco, Federico Carlos; Forrellad, Marina Andrea; Taibo, Catalina Beatriz; Klepp, Laura Ines; Sabio y Garcia, Julia Veronica; Nikel, Pablo I.; Jackson, Mary; Bigi, Fabiana (2016)
      Introduction The Mce proteins are encoded in a variable number of operons (from one to eight) in all Mycobacterium species. A role in the transport of host and mycobacterial lipids has been demonstrated for some Mce proteins ...

    • Mycobacterial MCE proteins as transporters that control lipid homeostasis of the cell wall 

      Klepp, Laura Ines; Sabio Y Garcia, Julia Veronica; Bigi, Fabiana (Elsevier, 2022-01)
      Mammalian cell entry (mce) genes are not only present in genomes of pathogenic mycobacteria, including Mycobacterium tuberculosis (the causative agent of tuberculosis), but also in saprophytic and opportunistic mycobacterial ...

    • Mycobacterium bovis mutant in the virulence factors PhoP, ESAT-6 and CFP-10 persisted in mouse organs after a year post-vaccination 

      Blanco, Federico Carlos; Vazquez, Cristina Lourdes; Garcia, Elizabeth Andrea; Rocha, Rosana Valeria; Klepp, Laura Ines; Bigi, Fabiana (Elsevier, 2024-12)
      A vaccine for bovine tuberculosis is urgently needed. The BCG vaccine (the Bacille Calmette-Guérin), currently the only licensed vaccine for tuberculosis in humans, offers variable protection in cattle. However, BCG is a ...

    • Production of functional bovine IL-22 in a mammalian episomal expression system 

      Klepp, Laura Ines; Bigi, María Mercedes; Villafañe, Luciana María; Blanco, Federico Carlos; Malinge, Pauline; Bigi, Fabiana (Elsevier, 2025-01)
      Interleukin 22 is a member of the interleukin-10 superfamily of cytokines. This protein has a dual role as an inflammatory and anti-inflammatory molecule dependent on the context. IL-22 is produced mainly by immune cells ...

    • Role of PhoPR in the response to stress of Mycobacterium bovis 

      Garcia, Elizabeth Andrea; Blanco, Federico Carlos; Klepp, Laura Ines; Pazos, Adriana Alejandra; McNeil, Michael; Jackson, Mary; Bigi, Fabiana (Elsevier, 2021-02)
      PhoP is part of the two-component PhoPR system that regulates the expression of virulence genes of Mycobacteria. The goal of this work was to elucidate the role of PhoP in the mechanism that Mycobacterium bovis, the causative ...

    • Rv2617c and P36 are virulence factors of pathogenic mycobacteria involved in resistance to oxidative stress 

      Forrellad, Marina Andrea; Vazquez, Cristina Lourdes; Blanco, Federico Carlos; Klepp, Laura Ines; Garcia, Elizabeth Andrea; Rocha, Rosana Valeria; Villafañe, Luciana Maria; Bigi, María Mercedes; Gutierrez, Maximiliano Gabriel; Bigi, Fabiana (Taylor & Francis, 2019-12)
      In this study, we characterized the role of Rv2617c in the virulence of Mycobacterium tuberculosis. Rv2617c is a protein of unknown function unique to M. tuberculosis complex (MTC) and Mycobacterium leprae. In vitro, this ...

    • Study of the in vivo role of Mce2R, the transcriptional regulator of mce2 operon in Mycobacterium tuberculosis 

      Forrellad, Marina Andrea; Bianco, María Veronica; Blanco, Federico Carlos; Nuñez, Javier; Klepp, Laura Ines; Vazquez, Cristina Lourdes; Santangelo, María De La Paz; Rocha, Rosana Valeria; Soria, Marcelo; Golby, Paul; Gutierrez, Maximiliano Gabriel; Bigi, Fabiana (BMC, 2013-09)
      Background: Tuberculosis is one of the leading causes of mortality throughout the world. Mycobacterium tuberculosis, the agent of human tuberculosis, has developed strategies involving proteins and other compounds called ...

    • Virulence factors of the Mycobacterium tuberculosis complex 

      Forrellad, Marina Andrea; Klepp, Laura Ines; Gioffre, Andrea; Sabio y Garcia, Julia Veronica; Morbidoni, Hector R.; Santangelo, María De La Paz; Cataldi, Angel Adrian; Bigi, Fabiana (Taylor & Francis, 2013-01)
      The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humans and animals. This illness, still today, remains to be one of the leading causes of morbidity and ...