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Mostrando ítems 1-12 de 12

    • A beginner’s guide for FMDV quasispecies analysis: sub-consensus variant detection and haplotype reconstruction using next-generation sequencing 

      Cacciabue, Marco Polo; Curra, Anabella Paola; Carrillo, Elisa Cristina; Konig, Guido Alberto; Gismondi, Maria Ines (Oxford Academic Press, 2020-09)
      Deep sequencing of viral genomes is a powerful tool to study RNA virus complexity. However, the analysis of next-generation sequencing data might be challenging for researchers who have never approached the study of viral ...

    • Antiviral efficacy of short-hairpin RNAs and artificial microRNAs targeting foot and-mouth disease virus 

      Curra, Anabella Paola; Cacciabue, Marco Polo Domingo; Gravisaco, María José; Asurmendi, Sebastian; Taboga, Oscar Alberto; Gismondi, Maria Ines (Peer J Inc., 2021-06)
      RNA interference (RNAi) is a well-conserved mechanism in eukaryotic cells that directs post-transcriptional gene silencing through small RNA molecules. RNAi has been proposed as an alternative approach for rapid and specific ...

    • Artificial microRNAs as antiviral strategy to FMDV: structural implications of target selection 

      Gismondi, Maria Ines; Ortiz, Xoana P.; Curra, Anabella Paola; Asurmendi, Sebastian; Taboga, Oscar Alberto (2014-04)
      RNA interference (RNAi) appears as a promising strategy to control virus replication. While the antiviral power of short-hairpin RNAs or small-interfering RNAs against FMDV has been demonstrated widely, safer RNAi effectors ...

    • Assessing the hidden diversity underlying consensus sequences of SARS-CoV-2 using VICOS, a novel bioinformatic pipeline for identification of mixed viral populations 

      Goya, Stephanie; Sosa, Ezequiel Jorge; Nabaes Jodar, Mercedes Soledad; Torres, Carolina; Konig, Guido Alberto; Acuña, Dolores; Ceballos, Santiago; Distefano, Ana Julia; Dopazo, Hernán; Dus Santos, Maria Jose; Fass, Monica Irinia; Fernandez Do Porto, Darío Augusto; Fernandez, Ailen; Gallego, Fernando; Gismondi, Maria Ines; Gramundi, Ivan; Lusso, Silvina; Marti, Marcelo Adrián; Mazzeo, Melina; Mistchenko, Alicia Susana; Muñoz Hidalgo, Marianne Graziel; Natale, Mónica; Nardi, Cristina; Ousset, Julia; Peralta, Andrea Veronica; Pintos, Carolina; Puebla, Andrea Fabiana; Pianciola, Luis; Rivarola, Maximo Lisandro; Turjanski, Adrián; Valinotto, Laura; Vera, Pablo Alfredo; Zaiat, Jonathan; Zubrycki, Jeremias Enrique; Aulicino, Paula; Viegas, Mariana (Elsevier, 2023-02)
      Introduction: Coinfection with two SARS-CoV-2 viruses is still a very understudied phenomenon. Although next generation sequencing methods are very sensitive to detect heterogeneous viral populations in a sample, there is ...

    • Baculovirus AcMNPV induces type I interferons and NK/NKT cells-mediated protection against foot-and-mouth disease virus in mice 

      Molina, Guido Nicolas; Cacciabue, Marco Polo; Gismondi, Maria Ines; Taboga, Oscar Alberto; Molinari, Maria Paula (Elsevier, 2020-08)
      Foot-and-mouth disease is a viral illness that affects cloven-hoofed animals causing serious economic losses. Inactivated vaccines against its causative agent, foot-and-mouth disease virus (FMDV), require approximately ...

    • Differential replication of Foot-and-mouth disease viruses in mice determine lethality 

      Cacciabue, Marco Polo; Garcia Nuñez, Maria Soledad; Delgado, Fernando Oscar; Curra, Anabella Paola; Marrero Diaz De Villegas, Rubén; Molinari, Maria Paula; Rieder, Elizabeth; Carrillo, Elisa Cristina; Gismondi, Maria Ines (2017-09)
      Adult C57BL/6J mice have been used to study Foot-and-mouth disease virus (FMDV) biology. In this work, two variants of an FMDV A/Arg/01 strain exhibiting differential pathogenicity in adult mice were identified and ...

    • Efficient edition of the bovine PRNP prion gene in somatic cells and IVF embryos using the CRISPR/Cas9 system 

      Bevacqua, Romina Jimena; Fernandez-Martín, R.; Savy, Virginia; Canel, Natalia Gabriela; Gismondi, Maria Ines; Kues, Wilfried A.; Carlson, Daniel F.; Fahrenkrug, S.C.; Niemann, H.; Taboga, Oscar Alberto; Ferraris, Sergio; Salamone, Daniel Felipe (2016-11)
      The recently developed engineered nucleases, such as zinc-finger nucleases, transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated nuclease ...

    • Genome-wide identification of microRNA targets in the neglected disease pathogens of the genus Echinococcus 

      Macchiaroli, Natalia; Maldonado, Lucas; Zarowiecki, Magdalena; Cucher, Marcela Alejandra; Gismondi, Maria Ines; Kamenetzky, Laura; Rosenzvit, Mara Cecilia (2017-06)
      MicroRNAs (miRNAs), a class of small non-coding RNAs, are key regulators of gene expression at posttranscriptional level and play essential roles in biological processes such as development. MiRNAs silence target mRNAs by ...

    • In vitro developmental competence of bovine demi-embryos generated by blastomere separation and blastocyst bisection 

      Ynsaurralde Rivolta, Amanda Eugenia; Gambini, Andrés; Alberio, Virgilia; Savy, Virginia; Ratner, Laura Daniela; Guberman, Alejandra; Vazquez Echegaray, Camila; Gismondi, Maria Ines; Curra, Anabella Paola; Bevacqua, Romina Jimena; Salamone, Daniel Felipe (Wiley, 2024-06)
      The efficiency of bovine in vitro embryo production can be significantly improved by splitting embryos at different stages. However, the blastocyst quality of in vitro-produced demi-embryos remains unexplored. The objective ...

    • Omicron Waves in Argentina: Dynamics of SARS-CoV-2 Lineages BA.1, BA.2 and the Emerging BA.2.12.1 and BA.4/BA.5 

      Torres, Carolina; Nabaes Jodar, Mercedes Soledad; Acuña, Dolores; Zambrana Montaño, Romina Micaela; Culasso, Andrés Carlos Alberto; Amadio, Ariel; Aulicino, Paula; Ceballos, Santiago; Cacciabue, Marco Polo Domingo; Debat, Humberto Julio; Dus Santos, Maria Jose; Eberhardt, María Florencia; Espul, Carlos; Fay, Fabián; Fernández, María Ailén; Fernandez, Franco Daniel; Fernandez Muñoz, Juan Manuel; Ferrini, Florencia; Gallego, Fernando; Giri, Adriana Angélica; Cerri, Agustina; Bolatti, Elisa; Gismondi, Maria Ines; Goya, Stephanie; Gramundi, Iván; Irazoqui, Jose Matias; Konig, Guido Alberto; Leiva, Viviana; Lucero, Horacio; Marquez, Nathalie; Nardi, Cristina; Ortiz, Belén; Pianciola, Luis; Pintos, Carolina Beatriz; Puebla, Andrea Fabiana; Rastellini, Carolina Victoria; Rojas, Alejandro Ezequiel; Sfalcin, Javier; Suárez, Ariel; Tittarelli, Estefanía; Toro, Rosana; Villanova, Gabriela Vanina; Ziehm, María Cecilia; Zimmermann, María Carla; Zunino, Sebastián; Proyecto PAIS Working Group; Valinotto, Laura; Viegas, Mariana (MDPI, 2023-01-22)
      The COVID-19 pandemic has lately been driven by Omicron. This work aimed to study the dynamics of SARS-CoV-2 Omicron lineages during the third and fourth waves of COVID-19 in Argentina. Molecular surveillance was performed ...

    • The Lambda Variant in Argentina: Analyzing the Evolution and Spread of SARS-CoV-2 Lineage C.37 

      Nabaes Jodar, Mercedes Soledad; Torres, Carolina; Mojsiejczuk, Laura; Acuña, Dolores; Valinotto, Laura Elena; Goya, Stephanie; Natale, Monica; Lusso, Silvina; Alexay, Sofia; Amadio, Ariel; Irazoqui, Jose Matias; Fernandez, Franco Daniel; Acevedo, Maria Elina; Alvarez Lopez, Cristina; Angelletti, Andres; Aulicino, Paula; Bolatti, Elisa; Brusés, Bettina; Cacciabue, Marco Polo Domingo; Cavatorta, Ana; Cerri, Agustina; Cordero, Andres; Debat, Humberto Julio; Dus Santos, Maria Jose; Eberhardt, María Florencia; Ercole, Regina; Espul, Carlos; Farber, Marisa Diana; Fay, Fabián; Fernandez, Ailen; Ferrini, Florencia; Formichelli, Laura; Ceballos, Santiago; Gallego, Fernando; Giri, Adriana; Gismondi, Maria Ines; Acevedo, Raúl Maximiliano; Gramundi, Ivan; Ibañez, María Eugenia; Konig, Guido Alberto; Leiva, Viviana; Lorenzini Campos, Melina; Lucero, Horacio; Marquez, Nathalie; Mazzeo, Melina; Mistchenko, Alicia Susana; Montoto, Luciana; Muñoz Hidalgo, Marianne Graziel; Nadalich, Victoria; Nardi, Cristina; Ortiz, Belén; Pianciola, Luis; Pintos, Carolina; Puebla, Andrea Fabiana; Rastellini, Carolina; Rojas, Alejandro Ezequiel; Sfalcin, Javier; Suarez, Ariel; Theaux, Clara; Thomas, Guillermo; Tittarelli, Estefania; Toro, Rosana; Villanova, Vanina; Wenk, Gretel; Ziehm, Cecilia; Zimmermann, Maria Carla; Zunino, Sebastian; Proyecto PAIS; Viegas, Mariana (MDPI, 2023-06-16)
      The second wave of COVID-19 occurred in South America in early 2021 and was mainly driven by Gamma and Lambda variants. In this study, we aimed to describe the emergence and local genomic diversity of the SARS-CoV-2 Lambda ...

    • ViralPlaque: a Fiji macro for automated assessment of viral plaque statistics 

      Cacciabue, Marco Polo; Curra, Anabella Paola; Gismondi, Maria Ines (PeerJ, 2019-09)
      laque assay has been used for a long time to determine infectious titers and characterize prokaryotic and eukaryotic viruses forming plaques. Indeed, plaque morphology and dimensions can provide information regarding the ...