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Characterization of two GH5 endoglucanases from termite microbiome using synthetic metagenomics
Ben Guerrero, Emiliano; Marrero Diaz De Villegas, Ruben; Soria, Marcelo Abel; Santangelo, María De La Paz; Campos, Eleonora; Talia, Paola Mónica (Springer, 2020-08)Here, we characterize two novel GH5 endoglucanases (GH5CelA and GH5CelB) from an uncultured bacterium identified in termite gut microbiomes. Both genes were codon-optimized, synthetized, cloned, and expressed as recombinant ... -
Development and diagnostic validation of an ELISA based on an antigenic mixture for the detection of bovine tuberculosis
Griffa, Natanael; Moyano, Roberto Damián; Canal, Ana María; Traveria, Gabriel Eduardo; Santangelo, María De La Paz; Alonso, Maria Natalia; Romano, Maria Isabel (Elsevier, 2020-02)Programs for the eradication of bovine tuberculosis (bTB) focus on the tuberculin skin test (TST) and slaughter of reactor cattle. However, the disease remains an animal health concern in several countries and improving ... -
Development of a lateral flow immunochromatography test for the rapid detection of bovine tuberculosis
Alonso, Maria Natalia; Griffa, Natanael; Moyano, Roberto Damián; Mon, Maria Laura; Colombatti Olivieri, Maria Alejandra; Barandiaran, Soledad; Martinez Vivot, Marcela; Fiorini, Gonzalo; Canal, Ana María; Santangelo, María De La Paz; Singh, Mahavir G.; Romano, Maria Isabel (Elsevier, 2021-04)Detection of specific antibodies would be a useful test strategy for bovine tuberculosis (bTB) as a complement to the single skin test. We developed a lateral flow immunochromatography (LFIC) test for rapid bTB detection ... -
Efficient method for targeted gene disruption by homologous recombination in Mycobacterium avium subspecie paratuberculosis
Alonso, Maria Natalia; Malaga, Wladimir; Mc Neil, Michael; Jackson, Mary; Romano, Maria Isabel; Guilhot, Christophe; Santangelo, María De La Paz (Elsevier, 2020-09)Targeted gene disruption by homologous recombination, has been widely used in mycobacterium species to understand the genetic basis of virulence and persistence in the host and to develop efficacious potential live vaccines. ... -
Evaluation of a virulent strain of Mycobacterium avium subsp. Paratuberculosis used as a heat-killed vaccine
Colombatti Olivieri, Maria Alejandra; Moyano, Roberto Damian; Mon, Maria Laura; Gravisaco, María José; Alvarado Pinedo, María Fiorella; Delgado, Fernando Oscar; Hernández Pando, Rogelio; Alonso, Maria Natalia; Cuerda, Maria Ximena; Santangelo, María De La Paz; Romano, Maria Isabel (Elsevier, 2021-11)Bovine paratuberculosis is one of the most important chronic infectious diseases in livestock. This disease is difficult to control because of its inefficient management (test and cull strategy and inadequate biosecurity). ... -
Genetic diversity of Mycobacterium avium complex strains isolated in Argentina by MIRU-VNTR
Imperiale, Belen Rocio; Moyano, Roberto Damian; Di Giulio, A.B.; Romero, M.A.; Alvarado Pinedo, Maria Fiorella; Santangelo, María De La Paz; Travería, G.E.; Morcillo, N.S.; Romano, Maria Isabel (2017-05)Mycobacterium avium sp. avium (MAA), M. avium sp. hominissuis (MAH), and M. avium sp. paratuberculosis (MAP) are the main members of the M. avium complex (MAC) causing diseases in several hosts. The aim of this study was ... -
Genetic diversity of Mycobacterium avium sp. Paratuberculosis by mycobacterial interspersed repetitive unit–variable number tandem repeat and multi‑locus short‑sequence repeat one‑sentence summary : genetic diversity of Mycobacterium avium sp. Paratuberculosis isolates
Moyano, Roberto Damián; Imperiale, Belen Rocio; Romero, Magalí; Santangelo, María De La Paz; Alvarado Pinedo, Maria Fiorella; Travería, Gabriel; Romano, Maria Isabel (Wolters Kluwer Medknow, 2021-03)Background: Paratuberculosis is an enteric disease caused by Mycobacterium avium sp. paratuberculosis (MAP) that affects mainly ruminant producing losses to the livestock industry. Many molecular epidemiological methods ... -
Genomic comparison of two strains of Mycobacterium avium subsp. paratuberculosis with contrasting pathogenic phenotype
Colombatti Olivieri, Maria Alejandra; Fresia, Pablo; Graña, Martín; Cuerda, Maria Ximena; Nagel, Ariel Gaston; Alvarado Pinedo, Maria Fiorella; Romano, Maria Isabel; Caimi, Karina Cynthia; Berná, Luisa; Santangelo, María De La Paz (Elsevier, 2023-01)In a previous study, we evaluated the degree of virulence of Mycobacterium avium subsp. paratuberculosis (Map) strains isolated from cattle in Argentina in a murine model. This assay allowed us to differentiate between ... -
Metabolic profile of mycobacterium smegmatis reveals Mce4 proteins are relevant for cell wall lipid homeostasis
Santangelo, María De La Paz; Heuberger, Adam; Blanco, Federico Carlos; Forrellad, Marina Andrea; Taibo, Catalina Beatriz; Klepp, Laura Ines; Sabio y Garcia, Julia Veronica; Nikel, Pablo I.; Jackson, Mary; Bigi, Fabiana (2016)Introduction The Mce proteins are encoded in a variable number of operons (from one to eight) in all Mycobacterium species. A role in the transport of host and mycobacterial lipids has been demonstrated for some Mce proteins ... -
Nuevas estrategias para el diagnóstico de la tuberculosis y paratuberculosis bovina
Mon, Maria Laura (Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2015-09)La Tuberculosis (TBB) y Paratuberculosis bovina (PTB) son las principales enfermedades que limitan el desarrollo de la industria lechera y de la carne en Argentina, siendo importantes en el contexto de la Sanidad animal ... -
Pathogenesis of domestic pigs submitted to mycobacterial sensitizations previous to experimental infection with Mycobacterium bovis
Cuerda, Maria Ximena; Colombatti Olivieri, Maria Alejandra; Gravisaco, María José; Marfil, Maria Jimena; Barandiaran, Soledad; Sevilla, Iker A.; Garrido, Joseba M.; Moyano, Roberto Damian; Zumarraga, Martin Jose; Romano, Maria Isabel; Juste, Ramón A.; Santangelo, María De La Paz (INIA (España), 2022-03)Aim of study: To demonstrate the virulence of a Mycobacterium bovis local pig isolate in order to contribute to a better understanding of the pathological and immunological consequences of M. bovis infection in previous ... -
Protection efficacy of Argentinian isolates of Mycobacterium avium subsp. paratuberculosis with different genotypes and virulence in a murine model
Colombatti Olivieri, Maria Alejandra; Moyano, Roberto Damian; Traveria, Gabriel Eduardo; Alvarado Pinedo, Maria Fiorella; Mon, Maria Laura; Gravisaco, María José; Delgado, Fernando Oscar; Santangelo, María De La Paz; Romano, Maria Isabel (Elsevier, 2018-12)Paratuberculosis is a chronic disease caused by Mycobacterium avium subsp. paratuberculosis (Map). The disease causes economic losses and, therefore, it is imperative to follow proper control strategies, which should include ... -
Relevancia clínica, diversidad y variabilidad genética de distintas especies del género Mycobacterium
Imperiale, Belen Rocio; Di Giulio, A.B.; Moyano, Roberto Damian; Santangelo, María De La Paz; Tártara, Silvina; Alonso, Viviana; Sanjurjo, Myriam; García, Graciela; Castellaro, Patricia; Romano, Maria Isabel; Morcillo, Nora (2017)Introducción: El término micobacterias no tuberculosas (MNT) incluye distintas especies ambientales capaces de enfermar humanosy/o animales incluso mediante una probable transmisión zoonótica Objetivos. Determinar: la ... -
Study of the in vivo role of Mce2R, the transcriptional regulator of mce2 operon in Mycobacterium tuberculosis
Forrellad, Marina Andrea; Bianco, María Veronica; Blanco, Federico Carlos; Nuñez, Javier; Klepp, Laura Ines; Vazquez, Cristina Lourdes; Santangelo, María De La Paz; Rocha, Rosana Valeria; Soria, Marcelo; Golby, Paul; Gutierrez, Maximiliano Gabriel; Bigi, Fabiana (BMC, 2013-09)Background: Tuberculosis is one of the leading causes of mortality throughout the world. Mycobacterium tuberculosis, the agent of human tuberculosis, has developed strategies involving proteins and other compounds called ... -
Virulence factors of the Mycobacterium tuberculosis complex
Forrellad, Marina Andrea; Klepp, Laura Ines; Gioffre, Andrea; Sabio y Garcia, Julia Veronica; Morbidoni, Hector R.; Santangelo, María De La Paz; Cataldi, Angel Adrian; Bigi, Fabiana (Taylor & Francis, 2013-01)The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humans and animals. This illness, still today, remains to be one of the leading causes of morbidity and ...