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A prime-boost combination of a three-protein cocktail and multiepitopic MVA as a vaccine against Babesia bigemina elicits neutralizing antibodies and a Th1 cellular immune response in mice
Montenegro, Valeria Noely; Jaramillo Ortiz, Jose; Paoletta, Martina; Gravisaco, María José; Del Medico Zajac, Maria Paula; Garanzini, Debora Patricia; Valenzano, Magali Nicole; Calamante, Gabriela; Wilkowsky, Silvina Elizabeth (Elsevier, 2022-09)In the intraerythrocytic protozoan parasites of the genus Babesia both innate and adaptive immune responses are necessary to confer protection against clinical disease. In particular, the adaptive immune response involves ... -
Aportes para la construcción de una propuesta de medición de impacto en el INTA
Curarello, Pablo Andres; Calamante, Gabriela; Claps, Leonardo; Perez, Gonzalo Antonio; Rozenblum, Constanza Beatriz; Martinez, Jose Matias (Ediciones INTA, 2020)El propósito de este libro es brindar un marco amplio y flexible de reflexión sobre los desafíos de introducir el enfoque de la evaluación de impacto en los diferentes escenarios de intervención INTA, para indagar en ... -
Canarypox virus expressing infectious bursal disease VP2 protein as immunogen for chickens
Zanetti, Flavia Adriana; Conte Grand, María Daniela; Mitarotonda, Romina Cristina; Taboga, Oscar Alberto; Calamante, Gabriela (Sociedade Brasileira de Microbiologia, 2014-05)Canarypox viruses (CNPV) carrying the coding sequence of VP2 protein from infectious bursal disease virus (IBDV) were obtained. These viruses were able to express VP2 protein in vitro and to induce IBDV-neutralizing ... -
Comparison of homologous and heterologous prime-boost immunizations combining MVA-vectored and plant-derived VP2 as a strategy against IBDV
Richetta, Matias Daniel; Gomez, Evangelina Raquel; Lucero, Maria Soledad; Chimeno Zoth, Silvina Andrea; Gravisaco, María José; Calamante, Gabriela; Berinstein, Analia (2017-01)Different immunogens such as subunit, DNA or live viral-vectored vaccines against Infectious Bursal Disease virus (IBDV) have been evaluated in the last years. However, the heterologous prime-boost approach using recombinant ... -
Deletion of A44L, A46R and C12L vaccinia virus genes from the MVA genome improved the vector immunogenicity by modifying the innate immune response generating enhanced and optimized specific T-Cell responses
Holgado, María Pía; Falivene, Juliana; Maeto, Cynthia; Amigo, Micaela; Pascutti, María Fernanda; Vecchione, María Belén; Bruttomesso, Andrea; Calamante, Gabriela; Del Medico Zajac, Maria Paula; Gherardi, Maria Magdalena (2016-05)MVA is an attenuated vector that still retains immunomodulatory genes. We have previously reported its optimization after deleting the C12L gene, coding for the IL-18 binding-protein. Here, we analyzed the immunogenicity ... -
Estrategia de inmunoprofilaxis para la prevención de la rabia paresiante utilizando un virus canarypox recombinante = Immunoprophylaxis strategy for the prevention of paralytic rabies using a recombinant canarypox virus
Garanzini, Debora Patricia; Rossner, Maria Victoria; Stahringer, Rodolfo Carlos; Micucci, Matías; Perez, Oscar; Del Medico Zajac, Maria Paula; Russo, Susana; Calamante, Gabriela (Servicio Nacional de Sanidad y Calidad Agroalimentaria (SENASA), 2015-03)La rabia paresiante es una enfermedad causada por el virus rábico transmitido por el vampiro común. En el norte de nuestro país, se registran anualmente un número limitado de casos por lo que es necesaria la implementación ... -
Identification and molecular characterization of Orf virus in Argentina
Peralta, Andrea Veronica; Robles, Carlos Alejandro; Martinez, Agustin; Alvarez, Lucia Paula; Valera, Alejandro; Calamante, Gabriela; Konig, Guido Alberto (Springer, 2015-06)Orf virus (ORFV) is the etiological agent of contagious ecthyma (CE), a pustular dermatitis of sheep and goats. Outbreaks of ORFV have been observed in all geographical regions of the world, including Argentina. The origin ... -
IL-12 DNA Displays efficient adjuvant effects improving immunogenicity of Ag85A in DNA prime/MVA boost immunizations
Morelli, María Paula; Del Medico Zajac, Maria Paula; Pellegrini, Joaquín Miguel; Amiano, Nicolás Oscar; Tateosian, Nancy Liliana; Calamante, Gabriela; Gherardi, Maria Magdalena; García, Verónica Edith (Frontiers Media, 2020-09)Mycobacterium tuberculosis (Mtb) infection is one of the leading causes of death worldwide. The Modified Vaccinia Ankara (MVA) vaccine vector expressing the mycobacterial antigen 85A (MVA85A) was demonstrated to be safe, ... -
Induction of both local immune response in mice and protection in a rabbit model by intranasal immunization with modified vaccinia ankara virus expressing a secreted form of bovine herpesvirus 1 glycoprotein D
Del Medico Zajac, Maria Paula; Zanetti, Flavia Adriana; Federico, Carlos Rodolfo; Zabal, Osvaldo Alfredo; Valera, Alejandro Rafael; Calamante, Gabriela (2017)In this study, we evaluated the immunogenicity and efficacy of mucosal delivery of a recombinant modified vaccinia Ankara virus (MVA) expressing the secreted version of bovine herpesvirus type 1 (BoHV-1) glycoprotein D ... -
MVAΔ008 viral vector encoding the model protein OVA induces improved immune response against the heterologous antigen and equal levels of protection in a mice tumor model than the conventional MVA
Del Medico Zajac, Maria Paula; Molinari, Maria Paula; Gravisaco, María José; Maizon, Daniel Omar; Moron, Victor Gabriel; Gherardi, Maria Magdalena; Calamante, Gabriela (Elsevier, 2021-11)Modified vaccinia Ankara virus (MVA) is extensively used as a vaccine vector. We have previously observed that MVAΔ008, an MVA lacking the gene that codes for interleukin-18 binding protein, significantly increases CD8+ ... -
Propuesta de aplicación de la Teoría del Cambio al Proceso de Gestión “Evaluación de Procedimientos” que realiza el Comité Institucional para el Cuidado y Uso de Animales de Experimentación (CICUAE) INTA CNIA.
Berinstein, Analia; Montanari, Ana Luisa; Calamante, Gabriela (Ediciones INTA; Centro de Investigación en Ciencias Veterinarias y Agronómicas (CICVyA), 2021)Este trabajo se focaliza en la evaluación del proceso de gestión de procedimientos experimentales/educativos/de servicio que involucran el uso de animales que los agentes de INTA deben presentar ante el Comité Institucional ... -
Protection against rabies induced by the non-replicative viral vectors MVA and Ad5 expressing rabies glycoprotein
Garanzini, Debora Patricia; Micucci, Matías; Torres Lopez, Annalies; Perez, Oscar; Calamante, Gabriela; Del Medico Zajac, Maria Paula (MDPI, 2025-04)Rabies is a zoonotic viral disease that is preventable through vaccination. Effective control strategies should follow the “One Health” concept, as targeting zoonotic pathogens at their animal source is the most effective ... -
Recombinant canarypox virus expressing the VP2 protein of infectious bursal disease virus induces protection in vaccinated SPF chickens
Zanetti, Flavia Adriana; Cardona, Romina; Federico, Carlos Rodolfo; Chimeno Zoth, Silvina Andrea; Calamante, Gabriela (2016)To study the in vivo distribution of the CNPV viral vector, we conducted two trials. In the first trial, six 11- day-old SPF chickens were intramuscularly vaccinated in one leg with CN048-VP2 (106 plaque-forming units ... -
Recombinant veterinary vaccines against rabies : state of art and perspectives
Del Medico Zajac, Maria Paula; Garanzini, Debora Patricia; Perez, Oscar; Calamante, Gabriela (Elsevier, 2020)The “One Health” concept summarized the idea that the health both of human and animal is interdependent and is bound to the health of the ecosystems in which they exist. This notion is supported and implemented by the World ... -
The MVA vector expressing the F protein of bovine respiratory syncytial virus is immunogenic in systemic and mucosal immunization routes = El vector viral MVA que expresa la proteína F del virus respiratorio sincicial bovino es inmunogénico al administrarse por vía sistémica y por mucosas
Ferella, Alejandra; Mozgovoj, Marina Valeria; Garanzini, Debora Patricia; Dus Santos, Maria Jose; Calamante, Gabriela; Del Medico Zajac, Maria Paula (Elsevier, 2023-12)Bovine respiratory syncytial virus (BRSV) affects both beef and dairy cattle, reaching morbidity and mortality rates of 60---80% and 20%, respectively. The aim of this study was to obtain a recombinant MVA expressing the ...