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Mostrando ítems 1-5 de 5

    • A direct high-throughput in Cell-ELISA for measuring infectivity of cytopathic and non-cytopathic bovine viral diarrhoea virus strains applied to the assessment of antiviral activity 

      Quintana, Maria Eugenia; Barone, Lucas; Forlenza, María Belén; Trotta, Myrian Vanesa; Turco, Cecilia; Mansilla, Florencia Celeste; Cardoso, Nancy Patricia; Capozzo, Alejandra Victoria (Elsevier, 2018-07-19)
      Low-cost high-throughput methods applicable to any virus strain are required for screening antiviral compounds against multiple field strains. Colorimetric cell-viability assays are used for this purpose as long as the ...

    • Bovine interferon lambda Is a potent antiviral against SARS-CoV-2 infection in vitro 

      Cardoso, Nancy; Mansilla, Florencia Celeste; Benedetti, Estefanía; Turco, Cecilia Soledad; Barone, Lucas Jose; Iserte, Javier Alonso; Soria, Ivana; Baumeister, Elsa; Capozzo, Alejandra (Frontiers Media, 2020-11)
      Interferon lambda (IFN-λ) is an antiviral naturally produced in response to viral infections, with activity on cells of epithelial origin and located in the mucosal surfaces. This localized activity results in reduced ...

    • In-vivo activity of IFN-λ and IFN-α against bovine-viral-diarrhea virus in a mouse model 

      Quintana, Maria Eugenia; Barone, Lucas Jose; Trotta, Myrian Vanesa; Turco, Cecilia Soledad; Mansilla, Florencia Celeste; Capozzo, Alejandra; Cardoso, Nancy (Frontiers Media, 2020-02)
      Bovine-viral-diarrhea virus (BVDV) can cause significant economic losses in livestock. The disease is controlled with vaccination and bovines are susceptible until vaccine immunity develops and may remain vulnerable if a ...

    • Interferon lambda protects cattle against bovine viral diarrhea virus infection 

      Quintana, Maria Eugenia; Cardoso, Nancy; Pereyra, Walter Rodrigo; Barone, Lucas Jose; Barrionuevo, Florencia Mariel; Mansilla, Florencia Celeste; Turco, Cecilia Soledad; Capozzo, Alejandra (Elsevier, 2020-12)
      Interferon lambda (IFN-λ) plays an important role in inducing an antiviral state in mucosal surfaces and has been used as an effective biotherapeutic against several viral diseases. Here we performed a proof of concept ...

    • Stable infection of a bovine mammary epithelial cell line (MAC-T) with bovine leukemia virus (BLV) 

      Martinez Cuesta, Lucia; Lendez, Pamela Anahi; Barone, Lucas; Perez, Sandra Elizabeth; Dolcini, Guillermina Laura; Ceriani, Maria Carolina; Nieto Farias, Maria Victoria (Elsevier, 2018)
      Bovine leukemia virus (BLV) is a retrovirus that affects cattle causing a lymphoproliferative disease. BLV infection has been associated with misbalance of the immune response causing a higher incidence of other infections. ...