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A direct high-throughput in Cell-ELISA for measuring infectivity of cytopathic and non-cytopathic bovine viral diarrhoea virus strains applied to the assessment of antiviral activity
Quintana, Maria Eugenia; Barone, Lucas; Forlenza, María Belén; Trotta, Myrian Vanesa; Turco, Cecilia; Mansilla, Florencia Celeste; Cardoso, Nancy Patricia; Capozzo, Alejandra Victoria (Elsevier, 2018-07-19)Low-cost high-throughput methods applicable to any virus strain are required for screening antiviral compounds against multiple field strains. Colorimetric cell-viability assays are used for this purpose as long as the ... -
Bovine interferon lambda Is a potent antiviral against SARS-CoV-2 infection in vitro
Cardoso, Nancy; Mansilla, Florencia Celeste; Benedetti, Estefanía; Turco, Cecilia Soledad; Barone, Lucas Jose; Iserte, Javier Alonso; Soria, Ivana; Baumeister, Elsa; Capozzo, Alejandra (Frontiers Media, 2020-11)Interferon lambda (IFN-λ) is an antiviral naturally produced in response to viral infections, with activity on cells of epithelial origin and located in the mucosal surfaces. This localized activity results in reduced ... -
Development and validation of a novel ELISA for the detection of Neospora caninum antibodies in bovine sera
Mansilla, Florencia Celeste; Gual, Ignacio; Pereyra, Walter Rodrigo; Cardoso, Nancy Patricia; Turco, Cecilia; Capozzo, Alejandra Victoria (Annex Publishers, 2019-08-26)Neospora caninum is a world-wide distributed apicomplexan parasite, causative agent of bovine neosporosis, which is one of the major causes of reproductive losses in cattle affecting both dairy and beef industries. Several ... -
Enhanced infectivity of bovine viral diarrhoea virus (BVDV) in arginase-producing bovine monocyte-derived macrophages
Barone, Lucas Jose; Cardoso, Nancy; Mansilla, Florencia Celeste; Castillo, Mariangeles; Capozzo, Alejandra (Taylor & Francis, 2024)Macrophages are important cells of the innate immunity that play a major role in Bovine Viral Diarrhoea Virus (BVDV) pathogenesis. Macrophages are not a homogenous population; they exist in different phenotypes, typically ... -
Foot-and-mouth disease vaccination induces cross-reactive IFN-γ responses in cattle that are dependent on the integrity of the 140S particles
Bucafusco, Danilo; Di Giacomo, Sebastián; Pega, Juan Franco; Schammas, Juan Manuel; Cardoso, Nancy Patricia; Capozzo, Alejandra Victoria; Perez Filgueira, Daniel Mariano (2015-02)Interferon-γ (IFN-γ) recall responses against foot-and-mouth disease virus (FMDV) in FMD vaccinated cattle are utilized to study T-lymphocyte immunity against this virus. Here, a recall IFN-γ assay based on a commercial ... -
Fusion of foreign T-cell epitopes and addition of TLR agonists enhance immunity against Neospora caninum profilin in cattle
Mansilla, Florencia Celeste; Quintana, Maria Eugenia; Cardoso, Nancy; Capozzo, Alejandra (2016)We demonstrated recently that immunization with recombinant Neospora caninum profilin (rNcPRO) induces limited protection and a regulatory T-cell response in mice. The aim of this study was to evaluate the immune response ... -
Immunization with Neospora caninum profilin induces limited protection and a regulatory T-cell response in mice
Mansilla, Florencia Celeste; Quintana, Maria Eugenia; Langellotti, Cecilia Ana; Wilda, Maximiliano; Martinez, Andrea; Fonzo, Adriana; Moore, Prando Dadin; Cardoso, Nancy; Capozzo, Alejandra (2016)Profilins are actin-binding proteins that regulate the polymerization of actin filaments. In apicomplexan parasites, they are essential for invasion. Profilins also trigger the immune response of the host by activating ... -
In vitro and in vivo characterization of a typical and a high pathogenic bovine viral diarrhea virus type ii strains
Malacari, Darío Amilcar; Pecora, Andrea; Perez Aguirreburialde, Maria Sol; Cardoso, Nancy Patricia; Odeon, Anselmo Carlos; Capozzo, Alejandra Victoria (Frontiers Media, 2018-04)Non-cytopathic (ncp) type 2 bovine viral diarrhea virus (BVDV-2) is widely prevalent in Argentina causing high mortality rates in cattle herds. In this study, we characterized an Argentinean ncp BVDV-2 field isolate (98-124) ... -
In-vivo activity of IFN-λ and IFN-α against bovine-viral-diarrhea virus in a mouse model
Quintana, Maria Eugenia; Barone, Lucas Jose; Trotta, Myrian Vanesa; Turco, Cecilia Soledad; Mansilla, Florencia Celeste; Capozzo, Alejandra; Cardoso, Nancy (Frontiers Media, 2020-02)Bovine-viral-diarrhea virus (BVDV) can cause significant economic losses in livestock. The disease is controlled with vaccination and bovines are susceptible until vaccine immunity develops and may remain vulnerable if a ... -
Interferon lambda protects cattle against bovine viral diarrhea virus infection
Quintana, Maria Eugenia; Cardoso, Nancy; Pereyra, Walter Rodrigo; Barone, Lucas Jose; Barrionuevo, Florencia Mariel; Mansilla, Florencia Celeste; Turco, Cecilia Soledad; Capozzo, Alejandra (Elsevier, 2020-12)Interferon lambda (IFN-λ) plays an important role in inducing an antiviral state in mucosal surfaces and has been used as an effective biotherapeutic against several viral diseases. Here we performed a proof of concept ... -
Prevalencia sérica de Neospora caninum y factores de riesgo asociados a su transmisión en tambos de la provincia de Salta, Argentina
Pereyra, Walter Rodrigo; Suarez, Victor Humberto; Cardoso, Nancy; Gual, Ignacio; Martinez, Gabriela Marcela; Capozzo, Alejandra; Mansilla, Florencia Celeste (Elsevier, 2020-09-11)El objetivo de este trabajo fue conocer la seroprevalencia de Neospora caninum en los bovinos de los tambos del Valle del Lerma (Salta, Argentina) y los factores de riesgo asociados a la transmisión de este parásito en ... -
Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses
Hollmann, Axel; Cardoso, Nancy; Espeche, Juan C.; Maffía, Paulo C. (Elsevier, 2021-08)Viruses remain one of the leading causes of animal and human disease. Some animal viral infections spread sporadically to human populations, posing a serious health risk. Particularly the emerging viral zoonotic diseases ... -
Serological screening of SARS-CoV-2 infection in companion animals of Buenos Aires suburbs
Cardoso, Nancy; Rivero, Carla; Castillo, Mariangeles; Mansilla, Florencia Celeste; Pastorino, Florencia; Piccirilli, Guadalupe; Alonso, Laura; Martinez, Gustavo; Di Lullo, David; Bentancor, Leticia Veronica; Capozzo, Alejandra (Frontiers Media, 2023-05)The Coronavirus Disease 2019 (COVID-19) is a zoonotic disease caused by the pandemic virus SARS-CoV-2. Domestic and wild animals are susceptible to infection and are potential reservoirs for virus variants. To date, there ...