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A transcriptional analysis of cattle immune cells reveals a central role of type 1 interferon in the In vitro innate immune response against Mycobacterium bovis
Blanco, Federico Carlos; Bigi, María Mercedes; Garcia, Elizabeth Andrea; Elola, María Teresa; Vazquez, Cristina Lourdes; Bigi, Fabiana (MDPI, 2023-09)Bovine tuberculosis is a chronic infectious disease primarily caused by Mycobacterium bovis, a bacterium that affects cattle and other mammals, including humans. Despite the availability of vast research about the immune ... -
Analysing nonsynonymous mutations between two Mycobacterium bovis strains with contrasting pathogenic profiles
Bigi, María Mercedes; Vazquez, Cristina Lourdes; Castelão, Ana Beatriz C.; Garcia, Elizabeth Andrea; Cataldi, Angel Adrian; Jackson, Mary; McNeil, Michael; Soria, Marcelo Abel; Zumarraga, Martin Jose; Cabruja, Matias; Gago, Gabriela; Blanco, Federico Carlos; Nishibe, Christiane; Almeida Junior, Nalvo Franco de; Araujo, Flabio Ribeiro de; Bigi, Fabiana (Elsevier, 2019-12)Mycobacterium bovis (M. bovis) is the causative agent of bovine tuberculosis, a chronic infectious disease that can affect cattle, other domesticated species, wild animals and humans. This disease produces important economic ... -
B cell and antibody responses in bovine tuberculosis
Klepp, Laura Ines; Blanco, Federico Carlos; Bigi, María Mercedes; Vazquez, Cristina Lourdes; Garcia, Elizabeth Andrea; Sabio Y Garcia, Julia Veronica; Bigi, Fabiana (MDPI, 2024-12)The development of vaccines and effective diagnostic methods for bovine tuberculosis requires an understanding of the immune response against its causative agent, Mycobacterium bovis. Although this disease is primarily ... -
Bovine macrophages responses to the infection with virulent and attenuated Leptospira interrogans serovar Pomona
Nagel, Ariel Gaston; Vazquez, Cristina Lourdes; Etulain, Julia; Blanco, Federico Carlos; Gravisaco, María José; Gomez, Ricardo Martín; Caimi, Karina Cynthia (Elsevier, 2019-06)Leptospirosis is a zoonosis, caused by pathogenic spirochetes of the genus Leptospira. Although cattle are usually the maintenance hosts of serovar Hardjo, Pomona is the most frequent serovar circulating in Argentina. The ... -
Characterization of the two component regulatory system PhoPR in Mycobacterium bovis
Garcia, Elizabeth Andrea; Blanco, Federico Carlos; Bigi, María Mercedes; Vazquez, Cristina Lourdes; Forrellad, Marina Andrea; Rocha, Rosana Valeria; Golby, Paul; Soria, Marcelo Abel; Bigi, Fabiana (Elsevier, 2018-08)Mycobacterium bovis is the causative agent of bovine tuberculosis and is a member of Mycobacterium tuberculosis complex, which causes tuberculosis in a number of mammals including humans. Previous studies have shown that ... -
Dynamics of the in vitro growing of Mycobacterium bovis from the lungs of vaccinated and infected mice
Blanco, Federico Carlos; Klepp, Laura Ines; Vazquez, Cristina Lourdes; Bigi, Fabiana (Wolters Kluwer Medknow, 2025-06)Background: Bovine tuberculosis (bTB) is a disease primarily caused by Mycobacterium bovis. Currently, no commercial vaccines exist for controlling bTB, making the development of effective vaccine candidates and testing ... -
FasR regulates fatty acid biosynthesis and is essential for virulence of Mycobacterium tuberculosis
Mondino, Sonia; Vazquez, Cristina Lourdes; Cabruja, Matias; Sala, Claudia; Cazenave-Gassiot, Amaury; Blanco, Federico Carlos; Wenk, Markus R.; Bigi, Fabiana; Cole, Stewart T.; Gramajo, Hugo; Gago, Gabriela (Frontiers Media, 2020-10)Mycobacterium tuberculosis, the etiologic agent of human tuberculosis, is the world’s leading cause of death from an infectious disease. One of the main features of this pathogen is the complex and dynamic lipid composition ... -
Long-term evaluation in BALBc mice of a triple mutant of Mycobacterium bovis and the Bacillus Calmette-Guérin as potential vaccines against bovine tuberculosis
Blanco, Federico Carlos; Marini, María Rocío; Klepp, Laura Ines; Vazquez, Cristina Lourdes; Garcia, Elizabeth Andrea; Bigi, María Mercedes; Canal, Ana María; Bigi, Fabiana (Elsevier, 2025-03)There is currently no commercial vaccine available against bovine tuberculosis (bTB). Mycobacterium bovis is the primary causative agent of bTB and is closely related to Mycobacterium tuberculosis, the pathogen responsible ... -
M72 Fusion proteins in nanocapsules enhance BCG efficacy against bovine tuberculosis in a mouse model
Blanco, Federico Carlos; Onnainty, Renée; Marini, María Rocío; Klepp, Laura Ines; Garcia, Elizabeth Andrea; Vazquez, Cristina Lourdes; Canal, Ana María; Granero, Gladys; Bigi, Fabiana (MDPI, 2025-06)Mycobacterium bovis is the causative pathogen of bovine tuberculosis (bTB), a disease that affects cattle and other mammals, including humans. Currently, there is no efficient vaccine against bTB, underscoring the need for ... -
Mycobacterium bovis mutant in the virulence factors PhoP, ESAT-6 and CFP-10 persisted in mouse organs after a year post-vaccination
Blanco, Federico Carlos; Vazquez, Cristina Lourdes; Garcia, Elizabeth Andrea; Rocha, Rosana Valeria; Klepp, Laura Ines; Bigi, Fabiana (Elsevier, 2024-12)A vaccine for bovine tuberculosis is urgently needed. The BCG vaccine (the Bacille Calmette-Guérin), currently the only licensed vaccine for tuberculosis in humans, offers variable protection in cattle. However, BCG is a ... -
Mycobacterium bovis requires P27 (LprG) to arrest phagosome maturation and replicate within bovine macrophages
Vazquez, Cristina Lourdes; Bianco, María Veronica; Blanco, Federico Carlos; Forrellad, Marina Andrea; Gutierrez, Maximiliano Gabriel; Bigi, Fabiana (2017-03)Mycobacterium bovis causes tuberculosis in a wide variety of mammals, with strong tropism for cattle and eventually humans. P27, also called LprG, is among the proteins involved in the mechanisms of the virulence and ... -
Rv2577 of Mycobacterium tuberculosis is a virulence factor with dual phosphatase and phosphodiesterase functions
Forrellad, Marina Andrea; Blanco, Federico Carlos; Marrero Diaz De Vill, Rubén; Vazquez, Cristina Lourdes; Yaneff, Agustín; Garcia, Elizabeth Andrea; Gutierrez, Maximiliano Gabriel; Durán, Rosario; Villarino, Andrea; Bigi, Fabiana (Frontiers Media, 2020-10)Tuberculosis, a lung disease caused by Mycobacterium tuberculosis (Mtb), is one of the ten leading causes of death worldwide affecting mainly developing countries. Mtb can persist and survive inside infected cells through ... -
Rv2617c and P36 are virulence factors of pathogenic mycobacteria involved in resistance to oxidative stress
Forrellad, Marina Andrea; Vazquez, Cristina Lourdes; Blanco, Federico Carlos; Klepp, Laura Ines; Garcia, Elizabeth Andrea; Rocha, Rosana Valeria; Villafañe, Luciana Maria; Bigi, María Mercedes; Gutierrez, Maximiliano Gabriel; Bigi, Fabiana (Taylor & Francis, 2019-12)In this study, we characterized the role of Rv2617c in the virulence of Mycobacterium tuberculosis. Rv2617c is a protein of unknown function unique to M. tuberculosis complex (MTC) and Mycobacterium leprae. In vitro, this ...