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Association of an IRF3 putative functional uORF variant with resistance to Brucella infection: A candidate gene based analysis of InDel polymorphisms in goats
Rossi, Ursula; Hasenauer, Flavia Carolina; Caffaro, María Eugenia; Raschia, Maria Agustina; Maurizio, Estefania; Cortez, Hector Sergio; Neumann, Roberto Daniel; Poli, Mario Andres; Rossetti, Carlos Alberto (Elsevier, 2019-03)Brucellosis is an important zoonotic disease caused by infection with Brucella spp. It generates major economic losses in livestock production worldwide. Goats are the principal hosts of B. melitensis, the main infection ... -
Association of TNF rs668920841 and INRA111 polymorphisms with caprine brucellosis: A case-control study of candidate genes involved in innate immunity
Hasenauer, Flavia Carolina; Rossi, Ursula; Caffaro, María Eugenia; Raschia, Maria Agustina; Maurizio, Estefanía; Poli, Mario Andres; Rossetti, Carlos Alberto (Elsevier, 2020-11)Caprine brucellosis is an infectious, contagious zoonotic disease caused by Brucella melitensis. Multiple factors, including host genetics, can influence the outcome of the exposure to Brucella; and it is expected that ... -
Caprine brucellosis : a historically neglected disease with significant impact on public health
Rossetti, Carlos Alberto; Arenas-Gamboa, Angela M.; Maurizio, Estefania (2017-08)Caprine brucellosis is a chronic infectious disease caused by the gram-negative cocci-bacillus Brucella melitensis. Middle- to late-term abortion, stillbirths, and the delivery of weak offspring are the characteristic ... -
Characterization of innate immune response to Brucella melitensis infection in goats with permissive or restrictive phenotype for Brucella intramacrophagic growth
Maurizio, Estefanía; Trangoni, Marcos David; Rossi, Ursula; Dunleavy, Mariana Victoria; Colato, Claudio; Rossetti, Carlos Alberto (Elsevier, 2021-04)Caprine brucellosis is a chronic, world-wide distributed disease which causes reproductive failure in goats and Brucella melitensis, its causative agent, bears a great zoonotic potential. There is evidence suggesting that ... -
Comparative review of brucellosis in small domestic ruminants
Rossetti, Carlos Alberto; Maurizio, Estefanía; Rossi, Ursula Amaranta (Frontiers Media, 2022-05)Brucella melitensis and Brucella ovis are the primary etiological agents of brucellosis in small domestic ruminants. B. melitensis was first isolated in 1887 by David Bruce in Malta Island from spleens of four soldiers, ... -
Cytokine expression profile of B. melitensis-infected goat monocyte-derived macrophages
Maurizio, Estefanía; Rossi, Ursula Amaranta; Trangoni, Marcos David; Rossetti, Carlos Alberto (Elsevier, 2023-05)Brucella parasitize the macrophage where is able to replicate and modulate the immune response in order to establish a chronic infection. The most adequate response to control and eliminate Brucella infection is a type 1 ... -
Deletion in KARLN intron 5 and predictive relationship with bovine tuberculosis and brucellosis infection phenotype
Rossi, Ursula Amaranta; Caffaro, María Eugenia; Raschia, Maria Agustina; Hasenauer, Flavia Carolina; Poli, Mario Andres; Rossetti, Carlos Alberto (Springer, 2023-06)Kalirin (gene: KALRN) is a Rho-GEF kinase linked to neurodegenerative diseases in humans. Unexpectedly, various polymorphisms in KALRN gene were previously associated with resistance to bacterial infections in ruminants. ... -
Desarrollo y evaluación de un ELISA de competición para la detección de anticuerpos anti -Brucella en suero y leche de rumiantes
Foster, Camila Nayla; Rossi, Ursula Amaranta; Saracino, María Priscila; Castaño Zubieta, Mirta Raquel; Baldi, Pablo C.; Rossetti, Carlos Alberto (Asociación Argentina de Veterinarios de Laboratorios de Diagnóstico, 2024-09)• El diagnóstico serológico es un insumo clave en los programas de control y erradicación de la brucelosis animal; • Las técnicas serológicas se dividen en pruebas tamiz (o screening) y pruebas complementarias (o ... -
Diferencias en la capacidad infectiva in vitro del género Brucella en macrófagos bovinos y murinos
Alvarez, María Candelaria; Rossi, Ursula Amaranta; Rossetti, Carlos Alberto (Universidad Nacional del Centro de la Provincia de Buenos Aires, 2023-08)Las especies del género Brucella son capaces de infectar un amplio rango de hospedadores, aunque presentan una preferencia jerárquica por determinadas especies de mamíferos (p.ej.: B. abortus: bovinos; B. melitensis: ... -
Evaluación preliminar de la polarización fluorescente como prueba DIVA en caprinos vacunados a distintas edades con la cepa Rev.1 de B. melitensis
Rossetti, Carlos Alberto; Foster, Camila Nayla; Olmos, Leandro Hipolito; Rossi, Ursula Amaranta; Castaño Zubieta, Mirta Raquel; Suarez, Victor Humberto (Asociación Argentina de Veterinarios de Laboratorios de Diagnóstico, 2024-09)• La vacunación anti-Brucella está indicada en las cabrillas pre-púberes; • La vacunación de los animales adultos genera anticuerpos persistentes que no se diferencian de los de una infección natural; • La prueba de ... -
Evaluation of B. melitensis whole-cell lysate antigen-based indirect ELISA for the serodiagnosis of caprine brucellosis
Foster, Camila Nayla; Rossi, Ursula Amaranta; Castaño Zubieta, Mirta Raquel; Vanzini, Victor Rene; Rossetti, Carlos Alberto (Elsevier, 2022-10)Different fractions of Brucella (B) abortus or Brucella melitensis have been used as antigens for the detection of anti-Brucella antibodies in goat sera, being their accomplishment cumbersome and time consuming. In an ... -
Evaluation of polymorphisms at the 3´ UTR SLC11A1 gene microsatellites and their associations with the outcome of Brucella abortus infection in Bos taurus cattle
Hasenauer, Flavia Carolina; Caffaro, María Eugenia; Poli, Mario Andres; Rossetti, Carlos Alberto (Ediciones INTA, 2022-11)In ruminants, polymorphisms in microsatellites at 3´untranslated region (3´ UTR) of the SLC11A1 gene were associated with natural resistance to Brucella spp. and Mycobacterium spp. infection, but its relevance to prevent ... -
Evaluation of the safety profile of the vaccine candidate Brucella melitensis 16MDvjbR strain in goats
Castaño Zubieta, Mirta Raquel; Rossetti, Carlos Alberto; Garcia-Gonzalez, Daniel G.; Maurizio, Estefanía; Hensel, Martha E.; Rice-Ficht, Allison C.; Ficht, Thomas A.; Arenas-Gamboa, Angela M. (Elsevier, 2021-01)Small ruminant brucellosis is caused by the Gram negative cocci-bacillus Brucella (B.) melitensis, the most virulent Brucella species for humans. In goats and sheep, middle to late-term gestation abortion, stillbirths and ... -
Exploring the association between polymorphisms at 3’UTR SLC11A1 gene microsatellites and resistance to tuberculosis: A case-control study in Bos taurus dairy cattle
Hasenauer, Flavia Carolina; Garbaccio, Sergio Gabriel; Caffaro, María Eugenia; Garro, Carlos Javier; Huertas, Pablo Sebastian; Poli, Mario Andres; Rossetti, Carlos Alberto (2018-04)Bovine tuberculosis is a contagious infectious disease that causes significant economic impact in dairy and meat farms throughout the world. Multiple factors, including host genome, determine the outcome of the infection. ... -
Genetic analysis of the 3′ untranslated region of the bovine SLC11A1 gene reveals novel polymorphisms
Hasenauer, Flavia Carolina; Caffaro, María Eugenia; Czibener, Cecilia; Comerci, Diego José; Poli, Mario Andres; Rossetti, Carlos Alberto (Springer, 2013-01)Polymorphisms in microsatellites at the 3′ untranslated region (3′UTR) of the SLC11A1 (solute carrier family 11 member A1) gene have been associated with natural resistance to Brucella abortus and Mycobacterium bovis ... -
Genetic resistance to infectious diseases : A complementary tool to antimicrobial drugs in livestock? = La resistencia genética a las enfermedades infecciosas : ¿una herramienta complementaria a las drogas antimicrobianas en la producción pecuaria?
Rossetti, Carlos Alberto; Rossi, Ursula Amaranta (Elsevier, 2025-07)A high percentage of the world's population depends on livestock for their sustenance. Therefore, animal health is closely linked to food safety and security, as it is essential to ensure that the food consumed is safe and ... -
A haplotype at intron 8 of PTPRT gene is associated with resistance to Brucella infection in Argentinian creole goats
Rossi, Ursula; Hasenauer, Flavia Carolina; Caffaro, María Eugenia; Neumann, Roberto Daniel; Salatin, Antonio Omar; Poli, Mario Andres; Rossetti, Carlos Alberto (2017-08)Brucellosis is the leading zoonosis on a worldwide scale and constitutes a major public health threat in many regions of the world. Several molecular markers associated with natural resistance to intracellular bacterial ... -
Human brucellosis and adverse pregnancy outcomes
Arenas-Gamboa, Angela M.; Rossetti, Carlos Alberto; Chaki, Sankar P.; Garcia-Gonzalez, Daniel G.; Adams, Leslie G.; Ficht, Thomas A. (Springer, 2016-12)Purpose of Review Brucellosis is a neglected, zoonotic disease of nearly worldwide distribution. Despite brucellosis being recognized as a reproductive disease in animals, it has been historically known as a flu-like ... -
An insertion in the caprine IRF3 gene affects macrophage response to B. melitensis infection
Rossi, Ursula Amaranta; Maurizio, Estefanía; Caffaro, María Eugenia; Poli, Mario Andres; Rossetti, Carlos Alberto (Universidad Nacional del Centro de la Provincia de Buenos Aires, 2023-08)Brucella melitensis is the etiological agent of brucellosis in goats and the main cause of human brucellosis. Interferons (IFNs) are important cytokines in the immune responses to intracellular pathogens and tumor cells. ... -
Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions
de Figueiredo, Paul; Ficht, Thomas A.; Rice-Ficht, Allison C.; Rossetti, Carlos Alberto; Adams, Leslie G. (Elsevier, 2015-06)This review of Brucellaehost interactions and immunobiology discusses recent discoveries as the basis for pathogenesis-informed rationales to prevent or treat brucellosis. Brucella spp., as animal pathogens, cause human ...