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A novel pathogenic DICER1 gene variant is associated with hereditary multinodular goiter in an Argentine family as evidenced by clinical, biochemical and molecular genetic analysis
Targovnik, Héctor M.; Barh, Debmalya; Papendieck, Patricia; Adrover, Ezequiela; Gallo, Ariel M.; Chiesa, Ana; Marques Da Silva, Wanderson; Azevedo, Vasco; Rivolta, Carina M. (Springer, 2025-03)DICER1 syndrome is an autosomal-dominant disorder that results in malignant or benign tumors. A number of distinct pathogenic germline and somatic variants have been identified as causing multinodular goiter (MNG). The ... -
An inhibitory mechanism of action of coiled‐coil peptides against type three secretion system from enteropathogenic Escherichia coli
Larzabal, Mariano; Baldoni, Hector A.; Suvire, Fernando D.; Curto, Lucrecia M.; Gomez, Gabriela E.; Marques Da Silva, Wanderson; Giudicessi, Silvana L.; Camperi, Silvia A.; Delfino, Jose M.; Cataldi, Angel Adrian; Enriz, Daniel (Wiley, 2019-03)Human pathogenic gram‐negative bacteria, such as enteropathogenic Escherichia coli (EPEC), rely on type III secretion systems (T3SS) to translocate virulence factors directly into host cells. The coiled‐coil domains present ... -
Humoral and cell-mediated immune response against the Mce2B (Rv0590/Mb0605) cell-wall protein of Mycobacterium bovis
Ferrara Muñiz, Ximena; Encinas, Micaela; Marques Da Silva, Wanderson; Garbaccio, Sergio Gabriel; Garro, Carlos Javier; Sammarruco, Romina Ayelén; Carignano, Hugo Adrian; Bianco, María Veronica; Cataldi, Angel Adrian; Zumarraga, Martin Jose; Eirin, Maria Emilia (Elsevier, 2025-06)Bovine tuberculosis is a zoonotic disease with global distribution. Improved diagnosis is essential thus, research into new diagnostic reagents is valuable. The Mce2B recombinant protein was evaluated as an inducer of ... -
Neutralisation of virulence activity of enterohemorrhagic Escherichia coli O157:H7 in vitro through hyperimmune bovine colostrum
Girón, Daniel; Marques Da Silva, Wanderson; Vilte, Daniel Alejandro; Smith, Libia Yael; Casabonne, Maria Carolina; Maldonado May, Veronica; Cataldi, Angel Adrian; Ibarra, Cristina Adriana; Larzabal, Mariano; Sacerdoti, Flavia (Wiley, 2025-07)Background, Context or Rationale Enterohemorrhagic Escherichia coli (EHEC) O157:H7 infection in humans may cause bloody diarrhoea, haemorrhagic colitis and haemolytic uremic syndrome (HUS). Cattle are the main reservoir ... -
Novel Effector Protein EspY3 of Type III Secretion System from Enterohemorrhagic Escherichia coli Is Localized in Actin Pedestals
Larzabal, Mariano; Marques Da Silva, Wanderson; Riviere, Nahuel Agustín; Cataldi, Angel Adrian (MDPI AG, 2018)Enterohemorrhagic Escherichia coli (EHEC) and enteropathogenic Escherichia coli (EPEC) are attaching and effacing (A/E) pathogens, which translocate effector proteins to intestinal enterocytes through a type III secretion ... -
Overexpressed proteins in hypervirulent clade 8 and clade 6 strains of Escherichia coli O157:H7 compared to E. coli O157:H7 EDL933 clade 3 strain
Amigo, Natalia; Qi, Zhang; Amadio, Ariel; Qunjie, Zhang; Marques da Silva, Wanderson; Baiyuan, Cui; Zhongjian, Chen; Larzabal, Mariano; Cataldi, Angel Adrian; Jinlong, Bei (2016)Escherichia coli O157:H7 is responsible for severe diarrhea and hemolytic uremic syndrome (HUS), and predominantly affects children under 5 years. The major virulence traits are Shiga toxins, necessary to develop HUS and ... -
Performance of the PhoP (Rv0757/Mb0780) protein as diagnostic antigen for bovine tuberculosis
Ferrara Muñiz, Ximena; Marques Da Silva, Wanderson; Garbaccio, Sergio Gabriel; Garro, Carlos Javier; Sammarruco, Romina Ayelén; Encinas, Micaela; Carignano, Hugo Adrian; Bianco, María Veronica; Zumarraga, Martin Jose; Cataldi, Angel Adrian; Eirin, Maria Emilia (Elsevier, 2025-03)Bovine tuberculosis (bTB), a global zoonotic disease, causes negative effects on human and animal health. PhoP protein is a key regulator of pathogenic phenotypes in members of the Mycobacterium tuberculosis complex, which ...