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Baculovirus AcMNPV induces type I interferons and NK/NKT cells-mediated protection against foot-and-mouth disease virus in mice
Molina, Guido Nicolas; Cacciabue, Marco Polo; Gismondi, Maria Ines; Taboga, Oscar Alberto; Molinari, Maria Paula (Elsevier, 2020-08)Foot-and-mouth disease is a viral illness that affects cloven-hoofed animals causing serious economic losses. Inactivated vaccines against its causative agent, foot-and-mouth disease virus (FMDV), require approximately ... -
Baculovirus transduction in mammalian cells is affected by the production of type I and III interferons, which is mediated mainly by the cGAS-STING pathway
Amalfi, Sabrina; Molina, Guido Nicolas; Bevacqua, Romina Jimena; Lopez, Maria Gabriela; Taboga, Oscar Alberto; Alfonso, Victoria (American Society for Microbiology, 2020-11)The baculovirus Autographa californica multiple nucleopolyhedrovirus is an insect virus with a circular double-stranded DNA genome, which, among other multiple biotechnological applications, is used as an expression vector ... -
Baculovirus vectors induce the production of interferons in swine : their potential in the development of antiviral strategies
Molina, Guido Nicolas; Amalfi, Sabrina; Otero, Ignacio; Taboga, Oscar Alberto; Molinari, Maria Paula (MDPI, 2021-11)The huge variety of viruses affecting swine represents a global threat. Since vaccines against highly contagious viruses last several days to induce protective immune responses, antiviral strategies for rapid control of ... -
The localization of a heterologous displayed antigen in the baculovirus-budded virion determines the type and strength of induced adaptive immune response
Tavarone, Maria Eugenia; Molina, Guido Nicolas; Amalfi, Sabrina; Peralta, Andrea Veronica; Molinari, Maria Paula; Taboga, Oscar Alberto; Diaz, Silvio Ricardo; Gravisaco, María José (2017-05)In the search of strategies of presentation of heterologous antigens to elicit humoral or cellular immune responses that modulate and properly potentiate each type of response, researchers have been studying baculovirus ... -
TLR9 activation is required for cytotoxic response elicited by baculovirus capsid display
Molinari, Maria Paula; Crespo, Maria Ines; Molina, Guido Nicolas; Dho, Nicolás D.; Marinho, Fábio V.; Maletto, Belkys Angélica; Leclerc, Claude; Oliveira, Sergio C.; Taboga, Oscar Alberto; Cebrian, Ignacio; Moron, Victor Gabriel (Wiley, 2023-05)Although the baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) infects lepidopteran invertebrates as natural hosts, represents an efficient vector for vaccine development. Baculovirus surface ... -
Two distinctive phenotypes of AcMNPV display different immune abilities and intracellular destiny
Molina, Guido Nicolas; Tavarone, Maria Eugenia; Taboga, Oscar Alberto; Molinari, Maria Paula (2016-12-29)The budded phenotype (BV) of the baculovirus AcMNPV has been demonstrated to have strong immunostimulatory properties that are relevant for the development of vaccines and antiviral therapies. Although the occluded ...