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A new cage-like particle adjuvant enhances protection of foot-and-mouth disease vaccine
Bidart, Juan Esteban; Kornuta, Claudia Alejandra; Gammella, Mariela; Gnazzo, Victoria; Soria, Ivana; Langellotti, Cecilia Ana; Mongini, Claudia; Galarza, Roxana Ivon; Calvinho, Luis Fernando; Lupi, Giuliana; Quattrocchi, Valeria; Marcipar, Ivan; Zamorano, Patricia Ines (Frontiers Media, 2020-07)Foot-and-Mouth Disease (FMD) is an acute viral disease that causes important economy losses. Vaccines with new low-cost adjuvants that stimulate protective immune responses are needed and can be assayed in a mouse model ... -
A plasmid encoding the extracellular domain of CD40 ligand and MontanideTM GEL01 as adjuvants enhance the immunogenicity and the protection induced by a DNA vaccine against BoHV-1
Kornuta, Claudia Alejandra; Langellotti, Cecilia Ana; Bidart, , Juan Esteban; Soria, Ivana; Quattrocchi, Valeria; Gammella, Mariela; Cheuquepan Valenzuela, Felipe; Mignaqui, Ana Clara; Ferraris, Sergio; Charleston, Bryan; Hecker, Yanina; Moore, Prando Dadin; Zamorano, Patricia Ines (Elsevier, 2021-02)DNA vaccines are capable of inducing humoral and cellular immunity, and are important to control bovine herpesvirus 1 (BoHV-1), an agent of the bovine respiratory disease complex. In previous work, a DNA plasmid that encodes ... -
Bovine dendritic cell activation, T cell proliferation and antibody responses to foot-and-mouth disease, is similar with inactivated virus and virus like particles
Quattrocchi, Valeria; Bidart, Juan Esteban; Mignaqui, Ana Clara; Ruiz, Vanesa; Ferella, Alejandra; Langellotti, Cecilia Ana; Gammella, Mariela; Ferraris, Sergio; Carrillo, Jorge Ernesto; Wigdorovitz, Andres; Durocher, Yves; Cardillo, Sabrina Beatriz; Charleston, Bryan; Zamorano, Patricia Ines (Frontiers Media, 2020-09)Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals that causes severe economic losses in the livestock industry. Currently available vaccines are based on the inactivated FMD virus (FMDV). ... -
Cápsides virales como vacunas contra el virus de la Fiebre Aftosa. Selección, potenciación y estudio de la respuesta inmune inducida
Bidart, Juan Esteban (Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2022-06-08)La Fiebre Aftosa (FA) es una enfermedad infectocontagiosa aguda, causada por el Virus de la Fiebre Aftosa (VFA). La enfermedad afecta a bovinos, ovinos, cerdos y varias especies silvestres, se caracteriza por la aparición ... -
FMD empty capsids combined with the immunostant particle adjuvant -ISPA or ISA206 induce protective immunity against foot and mouth disease virus
Bidart, Juan Esteban; Mignaqui, Ana Clara; Kornuta, Claudia Alejandra; Lupi, Giuliana; Gammella, Mariela; Soria, Ivana; Galarza, Roxana Ivon; Ferella, Alejandra; Cardillo, Sabrina Beatriz; Langellotti, Cecilia Ana; Quattrocchi, Valeria; Durocher, Yves; Wigdorovitz, Andres; Marcipar, Ivan; Zamorano, Patricia Ines (Elsevier, 2021-05)Foot and Mouth Disease Virus (FMDV) causes economy losses and is controlled by vaccination in many countries. Vaccine formulations based on empty capsids or Virus-Like Particles (VLPs) have the advantage of avoiding the ... -
Galectin-8 and GEL01 as potential adjuvants to enhance the immune response induced by a DNA vaccine against bovine alphaherpesvirus Type-1
Kornuta, Claudia Alejandra; Bidart, Juan Esteban; Soria, Ivana; Quattrocchi, Valeria; Gammella, Mariela; Tribulatti, María Virginia; Campetella, Oscar; Prato, Cecilia A.; Carabelli, Julieta; Cheuquepan Valenzuel, Felipe Andres; Hecker, Yanina; Moore, Prando Dadin; Zamorano, Patricia Ines; Langellotti, Cecilia Ana (Elsevier, 2025-03)Bovine alphaherpesvirus-1 (BoAHV-1) causes several symptoms in cattle, leading to significant costs for the livestock industry. In this study, we used a plasmid encoding a secreted form of BoAHV-1 glycoprotein D (pCIgD) ... -
MANα1-2MAN decorated liposomes enhance the immunogenicity induced by a DNA vaccine against BoHV-1
Kornuta, Claudia Alejandra; Bidart, , Juan Esteban; Soria, Ivana; Gammella, Mariela; Quattrocchi, Valeria; Pappalardo, Juan Sebastián; Salmaso, Stefano; Torchilin, Vladimir P.; Cheuquepan Valenzuel, Felipe Andres; Hecker, Yanina; Moore, Dadin P.; Zamorano, Patricia Ines; Langellotti, Cecilia Ana (Wiley, 2021-03)New technologies in the field of vaccinology arise as a necessity for the treatment and control of many diseases. Whole virus inactivated vaccines and modified live virus ones used against Bovine Herpesvirus‐1 (BoHV‐1) ... -
Optimized adenoviral vector that enhances the assembly of FMDV O1 virus-like particles in situ increases its potential as vaccine for serotype O viruses
Ziraldo, Micaela; Bidart, Juan Esteban; Prato, Cecilia A.; Tribulatti, María Virginia; Zamorano, Patricia Ines; Mattion, Nora Marta; D’Antuono, Alejandra (Frontiers Media, 2020-11)Although replication-defective human adenovirus type 5 (Ad5) vectors that express in situ the capsid-encoding region of foot-and-mouth disease virus (FMDV) have been proven to be effective as vaccines in relevant species ... -
TLR activation, immune response and viral protection elicited in cattle by a commercial vaccine against Bovine Herpesvirus-1
Kornuta, Claudia Alejandra; Cheuquepan Valenzuel, Felipe Andres; Bidart, , Juan Esteban; Soria, Ivana; Gammella, Mariela; Quattrocchi, Valeria; Hecker, Yanina; Moore, Prando Dadin; Romera, Sonia Alejandra; Marin, Maia Solange; Zamorano, Patricia Ines; Langellotti, Cecilia Ana (Elsevier, 2022-01)The innate and acquired immune response induced by a commercial inactivated vaccine against Bovine Herpesvirus-1 (BoHV-1) and protection conferred against the virus were analyzed in cattle. Vaccination induced high levels ...