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A Neospora caninum vaccine using recombinant proteins fails to prevent foetal infection in pregnant cattle after experimental intravenous challenge
Hecker, Yanina Paola; Cóceres, Verónica Mabel; Wilkowsky, Silvina Elizabeth; Jaramillo Ortiz, Jose Manuel; Morrell, Eleonora Lidia; Verna, Andrea Elizabeth; Ganuza, Agustina; Cano, Dora Beatriz; Lischinsky, Lilian Haydee; Ángel, Sergio Oscar; Zamorano, Patricia Ines; Odeon, Anselmo Carlos; Leunda, Maria Rosa; Campero, Carlos Manuel; Morein, Bror; Moore, Prando Dadin (Elsevier, 2014-12-15)The aim of the present study was to evaluate the immunogenicity and protective efficacy of rNcSAG1, rNcHSP20 and rNcGRA7 recombinant proteins formulated with immune stimulating complexes (ISCOMs) in pregnant heifers against ... -
A prime-boost combination of a three-protein cocktail and multiepitopic MVA as a vaccine against Babesia bigemina elicits neutralizing antibodies and a Th1 cellular immune response in mice
Montenegro, Valeria Noely; Jaramillo Ortiz, Jose; Paoletta, Martina; Gravisaco, María José; Del Medico Zajac, Maria Paula; Garanzini, Debora Patricia; Valenzano, Magali Nicole; Calamante, Gabriela; Wilkowsky, Silvina Elizabeth (Elsevier, 2022-09)In the intraerythrocytic protozoan parasites of the genus Babesia both innate and adaptive immune responses are necessary to confer protection against clinical disease. In particular, the adaptive immune response involves ... -
Desarrollo de candidatos vacunales contra Babesia bovis basados en vectores virales y proteínas recombinantes
Jaramillo Ortiz, Jose Manuel (Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2016-09)La babesiosis bovina es una enfermedad parasitaria trasmitida por garrapatas y causada por los protozooarios intraeritrocíticos Babesia bovis y B. bigemina. Esta infección provoca importantes pérdidas económicas en varias ... -
Desarrollo de inmunocromatografías para el diagnóstico de leptospirosis y neosporosis bovina
Montenegro, Valeria Noely; Varni, Vanina Delia; Nagel, Ariel Gaston; Jaramillo Ortiz, Jose Manuel; Paoletta, Martina; De La Fourniere, Sofia Ana María; Macoretta, Christian Leandro; Moore, Prando Dadin; Brihuega, Bibiana Felicitas; Caimi, Karina Cynthia; Wilkowsky, Silvina Elizabeth (2016)Los abortos en el ganado bovino implican pérdidas económicas en la industria pecuaria; los agentes infecciosos son una de las principales causas asociadas. Entre las diversas enfermedades identificadas en nuestro país como ... -
Development of an Indirect ELISA Based on a Recombinant Chimeric Protein for the Detection of Antibodies against Bovine Babesiosis
Jaramillo Ortiz, Jose Manuel; Montenegro, Valeria Noely; De La Fourniere, Sofia Ana María; Sarmiento, Nestor Fabian; Farber, Marisa Diana; Wilkowsky, Silvina Elizabeth (2018)The current method for Babesia spp. serodiagnosis based on a crude merozoite antigen is a complex and time-consuming procedure. An indirect enzyme-linked immunosorbent assay (iELISA) based on a recombinant multi-antigen ... -
Evaluation of different heterologous prime-boost immunization strategies against Babesia bovis using viral vectored and protein-adjuvant vaccines based on a chimeric multi-antigen
Jaramillo Ortiz, Jose Manuel; Molinari, Maria Paula; Gravisaco, María José; Paoletta, Martina; Montenegro, Valeria Noely; Wilkowsky, Silvina Elizabeth (2016)Protection against the intraerythrocytic bovine parasite Babesia bovis requires both humoral and cellular immune responses. Therefore, tailored combinations of immunogens targeted at both arms of the immune system are ... -
Identification and characterization of a Babesia bigemina thrombospondin-related superfamily member, TRAP-1 : a novel antigen containing neutralizing epitopes involved in merozoite invasion
Montenegro, Valeria Noely; Paoletta, Martina; Jaramillo Ortiz, Jose; Suarez, Carlos Esteban; Wilkowsky, Silvina Elizabeth (BioMed Central, 2020-12)Background: Thrombospondin-related anonymous protein (TRAP) has been described as a potential vaccine candidate for several diseases caused by apicomplexan parasites. However, this protein and members of this family have ... -
Immunisation of cattle against Babesia bovis combining a multi-epitope modified vaccinia Ankara virus and a recombinant protein induce strong Th1 cell responses but fails to trigger neutralising antibodies required for protection
Jaramillo Ortiz, Jose Manuel; Paoletta, Martina; Gravisaco, María José; Lopez Arias, Ludmila Sol; Montenegro, Valeria Noely; De La Fourniere, Sofia; Valenzano, Magali Nicole; Guillemi, Eliana Carolina; Valentini, Beatriz Susana; Echaide, Ignacio Eduardo; Farber, Marisa Diana; Wilkowsky, Silvina Elizabeth (Elsevier, 2019-10)Protection against the intraerythrocytic protozoan parasite Babesia bovis depends on both strong innate and adaptive immune response, this latter involving the presentation of parasite antigens to CD4+ T-lymphocytes by ... -
The key to egress? Babesia bovis perforin-like protein 1 (PLP1) with hemolytic capacity is required for blood stage replication and is involved in the exit of the parasite from the host cell
Paoletta, Martina; Laughery, Jacob Michael; Lopez Arias, Ludmila Sol; Jaramillo Ortiz, Jose; Montenegro, Valeria Noely; Petrigh, Romina; Ueti, Massaro W.; Suarez, Carlos Esteban; Farber, Marisa Diana; Wilkowsky, Silvina Elizabeth (Elsevier, 2021-07)Bovine babesiosis is a tick-borne disease caused by apicomplexan parasites of the Babesia genus that represents a major constraint to livestock production worldwide. Currently available vaccines are based on live parasites ...