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    • A safe and effective vaccine against bovine leukemia virus 

      Suarez Archilla, Guillermo; Gutierrez, Gerónimo; Camussone, Cecilia; Calvinho, Luis Fernando; Abdala, Alejandro Ariel; Alvarez, Irene; Petersen, Marcos; Franco, Lautaro Nahuel; De Stefano, Gabriel Alejandro; Monti, Gustavo; Jacques, Jean-Rock; Joris, Thomas; Willems, Luc; Trono, Karina Gabriela (Frontiers Media, 2022-08)
      Previous attempts to develop a vaccine against bovine leukemia virus (BLV) have not been successful because of inadequate or short-lived stimulation of all immunity components. In this study, we designed an approach based ...

    • An efficient vaccine against bovine leukemia virus 

      Gutierrez, Gerónimo; Rodríguez, Sabrina M.; Vilor, Agustín; Gillet, Nicolas A.; DeBrogniez, Alix; Trono, Karina Gabriela; Willems, Luc (BioMed Central, 2015)
      Previous attempts to produce a vaccine against BLV faced problems of efficacy (i.e. only a fraction of animals were protected), persistence (i.e. rapid decrease of immune protection), cost (e.g. production of purified ...

    • BOLA-DRB3 gene polymorphisms influence bovine leukaemia virus infection levels in Holstein and Holstein × Jersey crossbreed dairy cattle 

      Carignano, Hugo Adrian; Beribe, Maria Jose; Caffaro, Marí­a Eugenia; Amadio, Ariel; Nani, Juan Pablo; Gutierrez, Gerónimo; Alvarez, Irene; Trono, Karina Gabriela; Miretti, Marcos Mateo; Poli, Mario Andres (2017-05)
      Bovine leukemia virus (BLV) infections, causing persistent lymphocytosis and lethal lymphosarcoma in cattle, have reached high endemicity on dairy farms. We observed extensive inter-individual variation in the level of ...

    • Bovine leukemia virus becomes established in dairy herds before the first lactation 

      Merlini, Ramiro; Gutierrez, Gerónimo; Alvarez, Irene; Jaworski, Juan Pablo; Carignano, Hugo Adrian; Poli, Mario Andres; Willems, Luc; Trono, Karina Gabriela (2016)
      In this work, we studied seven groups of pregnant heifers from a consortium of dairy farms heavily infected with bovine leukemia virus (BLV). ELISA testing showed that the seroprevalence ranges of BLV in heifers between ...

    • Bovine leukemia virus small noncoding RNAs are functional elements that regulate replication and contribute to oncogenesis in vivo 

      Gillet, Nicolas A.; Hamaidia, Malik; Brogniez, Alix de; Gutierrez, Gerónimo; Renotte, Nathalie; Reichert, Michal; Trono, Karina Gabriela; Willems, Luc (2016-04)
      Retroviruses are not expected to encode miRNAs because of the potential problem of self-cleavage of their genomic RNAs. This assumption has recently been challenged by experiments showing that bovine leukemia virus (BLV) ...

    • Characterization of colostrum from dams of BLV endemic dairy herds 

      Gutierrez, Gerónimo; Lomonaco, Marina; Alvarez, Irene; Fernandez, Fernando; Trono, Karina Gabriela (Elsevier, 2015-06)
      Bovine Leukemia Virus (BLV) is endemic in Argentina, where the individual prevalence is higher than 80% in dairy farms. The aim of this work was to find preliminary evidence to know if the high level of infection of the ...

    • Dynamics of perinatal bovine leukemia virus infection 

      Gutierrez, Gerónimo; Alvarez, Irene; Merlini, Ramiro; Rondelli, Flavia; Trono, Karina Gabriela (BioMed Central, 2014)
      Bovine leukemia virus (BLV) is highly endemic in many countries, including Argentina. As prevention of the spread from infected animals is of primary importance in breaking the cycle of BLV transmission, it is important ...

    • Efficacy of the spray-drying treatment to inactivate the bovine leukemia virus in bovine colostrum 

      Lomonaco, Marina; Sowul, Mariana; Gutierrez, Gerónimo; Malacari, Darío Amilcar; Alvarez, Irene; Porta, Natalia Gabriela; Zabal, Osvaldo Alfredo; Trono, Karina Gabriela (Elsevier, 2020-07)
      Previous studies have shown the presence of bovine leukemia virus (BLV) in colostrum and milk of naturally infected cows. The relationship between virus or provirus and specific antibodies in these secretions is particular ...

    • Evaluation of total white blood cell count as a marker for proviral load of bovine leukemia virus in dairy cattle from herds with a high seroprevalence of antibodies against bovine leukemia virus 

      Alvarez, Irene; Gutierrez, Gerónimo; Gammella, Mariela; Martínez, Cecilia; Politzki, Romina Paula; González, Cintia Beatríz; Caviglia, Luciana; Carignano, Hugo; Fondevila, Norberto Antonio; Poli, Mario Andres; Trono, Karina Gabriela (2013-05)
      Objective—To determine the reference interval for WBC counts in Holstein dairy cows from herds with high seroprevalence for anti–bovine leukemia virus (BLV) antibodies, analyze the correlation of total WBC counts and blood ...

    • Genome-wide scan for commons SNPs affecting bovine leukemia virus infection level in dairy cattle 

      Carignano, Hugo Adrian; Roldan, Dana Leticia; Beribe, Maria Jose; Raschia, Maria Agustina; Amadio, Ariel; Nani, Juan Pablo; Gutierrez, Gerónimo; Alvarez, Irene; Trono, Karina Gabriela; Poli, Mario Andres; Miretti, Marcos Mateo (2018-02-13)
      Background: Bovine leukemia virus (BLV) infection is omnipresent in dairy herds causing direct economic losses due to trade restrictions and lymphosarcoma-related deaths. Milk production drops and increase in the culling ...

    • Influencia de las condiciones de incubación en la detección de anticuerpos contra el Virus de la Leucosis bovina por ELISA = Influence of the incubation conditions on the detection of antibodies to bovine leukemia virus by ELISA 

      Lomonaco, Marina; Martinez, Cecilia; Alvarez, Irene; Gutierrez, Gerónimo; Politzki, Romina Paula; Trono, Karina Gabriela (Sociedad de Medicina Veterinaria, 2013-05)
      En este trabajo se modificaron las condiciones de incubación del ensayo de ELISAp24 que detecta anticuerpos contra el Virus de la Leucosis bovina, con el propósito de evaluar si se reduce el número de resultados falsos y ...

    • Recent advances in BLV research 

      Barez, Pierre-Yves; De Brogniez, Alix; Carpentier, Alexandre; Gazon, Hélène; Gillet, Nicolas; Gutierrez, Gerónimo; Hamaidia, Malik; Jacques, Jean-Rock; Perike, Srikanth; Sriramareddy, Sathya Neelature; Renotte, Nathalie; Staumont, Bernard; Reichert, Michal; Trono, Karina Gabriela; Willems, Luc (MDPI, 2015-11)
      Different animal models have been proposed to investigate the mechanisms of Human T-lymphotropic Virus (HTLV)-induced pathogenesis: rats, transgenic and NOD-SCID/γcnull (NOG) mice, rabbits, squirrel monkeys, baboons and ...

    • Short communication: Relationship between the level of bovine leukemia virus antibody and provirus in blood and milk of cows from a naturally infected herd 

      Jaworski, Juan Pablo; Porta, Natalia Gabriela; Gutierrez, Gerónimo; Politzki, Romina Paula; Alvarez, Irene; Galarza, Roxana Ivon; Abdala, Alejandro Ariel; Calvinho, Luis Fernando; Trono, Karina Gabriela (2016)
      We explored the relationship between the level of bovine leukemia virus antibodies and provirus load during natural infection. For that purpose, a set of 50 blood and milk paired samples were analyzed for the presence of ...

    • Vaccination against δ-retroviruses : the bovine leukemia virus paradigm 

      Gutierrez, Gerónimo; Rodriguez, Sabrina M.; de Brogniez, Alix; Gillet, Nicolas A.; Golime, Ramarao; Burny, Arsene; Jaworski, Juan Pablo; Alvarez, Irene; Vagnoni, Lucas Emilio; Trono, Karina Gabriela; Willems, Luc (2014-06)
      Bovine leukemia virus (BLV) and human T-lymphotropic virus type 1 (HTLV-1) are closely related d-retroviruses that induce hematological diseases. HTLV-1 infects about 15 million people worldwide, mainly in subtropical ...