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    • Balance between retroviral latency and transcription : based on HIV model 

      Pluta, Aneta; Jaworski, Juan Pablo; Cortés-Rubio, César N. (MDPI, 2021-01)
      The representative of the Lentivirus genus is the human immunodeficiency virus type 1 (HIV-1), the causative agent of acquired immunodeficiency syndrome (AIDS). To date, there is no cure for AIDS because of the existence ...

    • Bovine leukemia virus becomes established in dairy herds before the first lactation 

      Merlini, Ramiro; Gutierrez, Gerónimo; Alvarez, Irene; Jaworski, Juan Pablo; Carignano, Hugo Adrian; Poli, Mario Andres; Willems, Luc; Trono, Karina Gabriela (2016)
      In this work, we studied seven groups of pregnant heifers from a consortium of dairy farms heavily infected with bovine leukemia virus (BLV). ELISA testing showed that the seroprevalence ranges of BLV in heifers between ...

    • Bovine leukemia virus encoded blv-miR-b4-3p microRNA is associated with reduced expression of anti-oncogenic gene in vivo 

      Petersen, Marcos Iván; Carignano, Hugo Adrian; Mongini, Claudia; Gonzalez, Diego D.; Jaworski, Juan Pablo (PLOS, 2023-02)
      Bovine leukemia virus (BLV) is a retrovirus that causes malignant B-cell lymphoma in up to ten-percent of infected cattle. To date, the mechanisms of BLV linked to malignant transformation remain elusive. Although BLV-encoded ...

    • Co-expression of bovine leukemia virus and bovine foamy virus-derived miRNAs in naturally infected cattle 

      Petersen, Marcos Iván; Suarez Archilla, Guillermo; Perez, C.V.; Gonzalez, Diego D.; Trono, Karina Gabriela; Mongini, Claudia; Jaworski, Juan Pablo; Carignano, Hugo Adrian (2025-09)
      Among the viruses that encode microRNAs (miRNAs) and infect cattle, such as bovine leukemia virus (BLV), bovine foamy virus (BFV), and Bovine herpesviruses, BLV has gained attention due to the critical role that BLV-miRNAs ...

    • Inter-laboratory comparison of eleven quantitative or digital PCR assays for detection of proviral bovine leukemia virus in blood samples 

      Pluta, Aneta; Jaworski, Juan Pablo; Droscha, Casey; VanderWeele, Sophie; Taxis, Tasia M.; Valas, Stephen; Brnić, Dragan; Jungić, Andreja; Ruano, María José; Sánchez, Azucena; Murakami, Kenji; Nakamura, Kurumi; Puentes, Rodrigo; De Brun, María L.; Ruiz, Vanesa; Ladera Gómez, Marla Eliana; Lendez, Pamela Anahí; Dolcini, Guillermina Laura; Fernandes Camargos, Marcelo; Fonseca, Antonio; Barua, Subarna; Wang, Chengming; Giza, Aleksandra; Kuźmak, Jacek (BioMed Central, 2024-08)
      Bovine leukemia virus (BLV) is the etiological agent of enzootic bovine leukosis and causes a persistent infection that can leave cattle with no symptoms. Many countries have been able to successfully eradicate BLV through ...

    • Neutralizing monoclonal antibodies to fight HIV-1 : on the threshold of success 

      Jaworski, Juan Pablo; Vendrell, Alejandrina; Chiavenna, Sebastián Matias (2017)
      Anti-human immunodeficiency virus type-1 (anti-HIV-1) neutralizing monoclonal antibodies are broadening the spectrum of pre- and post-exposure treatment against HIV-1. A better understanding of how these antibodies develop ...

    • Short communication: Relationship between the level of bovine leukemia virus antibody and provirus in blood and milk of cows from a naturally infected herd 

      Jaworski, Juan Pablo; Porta, Natalia Gabriela; Gutierrez, Gerónimo; Politzki, Romina Paula; Alvarez, Irene; Galarza, Roxana Ivon; Abdala, Alejandro Ariel; Calvinho, Luis Fernando; Trono, Karina Gabriela (2016)
      We explored the relationship between the level of bovine leukemia virus antibodies and provirus load during natural infection. For that purpose, a set of 50 blood and milk paired samples were analyzed for the presence of ...

    • Spontaneous virus reactivation in cattle chronically infected with bovine leukemia virus 

      Jaworski, Juan Pablo; Petersen, Marcos Iván; Carignano, Hugo; Trono, Karina Gabriela (BioMed Central, 2019)
      Background: The absence of virus expression during the chronic stage of bovine leukemia virus (BLV) infection and its reactivation upon ex vivo culture has become a long-lived Dogma. During the chronic stage of BLV ...

    • State of the art in anti-cancer mAbs 

      Chiavenna, Sebastián Matias; Jaworski, Juan Pablo; Vendrell, Alejandrina (2017-02-20)
      Following Milstein’s discovery, the monoclonal antibodies (mAbs) became a basic tool for biomedical science. In cancer field, since the first mAb was approved by the FDA a great improvement took place making of them a ...

    • Vaccination against δ-retroviruses : the bovine leukemia virus paradigm 

      Gutierrez, Gerónimo; Rodriguez, Sabrina M.; de Brogniez, Alix; Gillet, Nicolas A.; Golime, Ramarao; Burny, Arsene; Jaworski, Juan Pablo; Alvarez, Irene; Vagnoni, Lucas Emilio; Trono, Karina Gabriela; Willems, Luc (2014-06)
      Bovine leukemia virus (BLV) and human T-lymphotropic virus type 1 (HTLV-1) are closely related d-retroviruses that induce hematological diseases. HTLV-1 infects about 15 million people worldwide, mainly in subtropical ...