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A Novel Vaccine for Bovine Diarrhea Complex Utilizing Recombinant Enterotoxigenic Escherichia coli and Salmonella Expressing Surface-Displayed Chimeric Antigens from Enterohemorrhagic Escherichia coli O157:H7
Ramírez, Hernán; Vilte, Daniel Alejandro; Hozbor, Daniela Flavia; Zurita, Eugenia; Bottero, Daniela; Casabonne, Maria Carolina; Cataldi, Angel Adrian; Wigdorovitz, Andres; Larzabal, Mariano (MDPI, 2025-02)Background/Objectives: Enterohemorrhagic Escherichia coli (EHEC) O157:H7, a zoonotic pathogen primarily found in cattle, causes Hemolytic Uremic Syndrome (HUS) in humans, often through contaminated food. Its Type Three ... -
A one-year longitudinal study of enterohemorrhagic Escherichia coli O157 fecal shedding in a beef cattle herd
Rhades, Luis; Larzabal, Mariano; Bentancor, Adriana; Sabio Y Garcia, Julia Veronica; Babinec, Francisco Jose; Cataldi, Angel Adrian; Amigo, Natalia; Baldone, Valeria Natalia; Urquiza, Lucas Federico; Delicia, Pablo Javier; Fort, Marcelo Cristian (Elsevier, 2019-12-01)Bovines are the primary reservoir of enterohemorrhagic Escherichia coli (EHEC) O157:H7 and the main source of its transmission to humans. Here, we present a one-year longitudinal study of fecal shedding of E. coli O157. ... -
An inhibitory mechanism of action of coiled‐coil peptides against type three secretion system from enteropathogenic Escherichia coli
Larzabal, Mariano; Baldoni, Hector A.; Suvire, Fernando D.; Curto, Lucrecia M.; Gomez, Gabriela E.; Marques Da Silva, Wanderson; Giudicessi, Silvana L.; Camperi, Silvia A.; Delfino, Jose M.; Cataldi, Angel Adrian; Enriz, Daniel (Wiley, 2019-03)Human pathogenic gram‐negative bacteria, such as enteropathogenic Escherichia coli (EPEC), rely on type III secretion systems (T3SS) to translocate virulence factors directly into host cells. The coiled‐coil domains present ... -
Clade 8 and clade 6 strains of Escherichia coli O157:H7 from cattle in Argentina have Hypervirulent-Like phenotypes
Amigo, Natalia; Mercado, Elsa Cristina; Bentancor, Adriana Beatriz; Singh, Pallavi; Vilte, Daniel Alejandro; Gerhardt, Elizabeth; Zotta, Elsa; Ibarra, Cristina Adriana; Manning, Shannon D.; Larzabal, Mariano; Cataldi, Angel Adrian (PLOS, 2015-06-01)The hemolytic uremic syndrome (HUS) whose main causative agent is enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a disease that mainly affects children under 5 years of age. Argentina is the country with the highest ... -
Early immune innate hallmarks and microbiome changes across the gut during Escherichia coli O157: H7 infection in cattle
Larzabal, Mariano; Marques Da Silva, Wanderson; Multani, Anmol; Vagnoni, Lucas Emilio; Moore, Prando Dadin; Marin, Maia Solange; Riviere, Nahuel Agustin; Delgado, Fernando Oscar; Vilte, Daniel Alejandro; Romero Victorica, Matias; Tao, Ma; Luo, Le Guan; Talia, Paola Mónica; Cataldi, Angel Adrian; Cobo, Eduardo Rubén (SpringerNature, 2020-12)The zoonotic enterohemorrhagic Escherichia coli (EHEC) O157: H7 bacterium causes diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome (HUS) in humans. Cattle are primary reservoirs and EHEC O157: H7; the bacteria ... -
Enterohemorrhagic Escherichia coli O157:H7 antigens produced in transgenic lettuce effective as an oral vaccine in mice
Su, Yun‑Lin; Larzabal, Mariano; Song, Huan; Cheng, Tianfang; Wang, Yufang; Smith, Libia Yael; Cataldi, Angel Adrian; Ow, David W. (Springer, 2023-10)Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a food-borne pathogen where ruminant farm animals, mainly bovine, serve as reservoirs. Bovine vaccination has been used to prevent disease outbreaks, and the current ... -
Estudio de los factores de riesgo asociados a la excreción de escherichia coli o157:H7 en bovinos
Rhades, Luis; Larzabal, Mariano; Bentancor, Adriana; Sabio Y Garcia, Julia Veronica; Babinec, Francisco Jose; Cataldi, Angel Adrian; Amigo, Natalia; Baldone, Valeria Natalia; Urquiza, Lucas Federico; Delicia, Pablo Javier; Fort, Marcelo Cristian (Asociación Argentina de Microbiología, 2022-04-20)Los bovinos son reservorios primarios de Escherichia coli enterohemorrágica (EHEC) O157: H7, bacteria responsable del síndrome urémico hemolítico (SUH) que afecta a niños menores de 6 años en forma endémica en la Argentina, ... -
Genomic analysis of shiga toxin-containing Escherichia coli O157:H7 isolated from Argentinean cattle
Amadio, Ariel; Bono, James L.; Irazoqui, Jose Matias; Larzabal, Mariano; Marques Da Silva, Wanderson; Eberhardt, María Florencia; Riviere, Nahuel Agustin; Gally, David; Manning, Shannon D.; Cataldi, Angel Adrian (Plos, 2021-10)Cattle are the main reservoir of Enterohemorrhagic Escherichia coli (EHEC), with O157:H7 the distinctive serotype. EHEC is the main causative agent of a severe systemic disease, Hemolytic Uremic Syndrome (HUS). Argentina ... -
Immunohistochemical detection of pro-inflammatory and anti-inflammatory cytokines in granulomas in cattle with natural Mycobacterium bovis infection
Canal, Ana María; Pezzone, Natalia; Cataldi, Angel Adrian; Zumarraga, Martin Jose; Larzabal, Mariano; Garbaccio, Sergio Gabriel; Fernández, Analía; Dominguez, Lucas; Aranaz, Alicia; Rodriguez-Bertos, Antonio (2017)Cellular immune response was evaluated in lymph nodes and lung with different granulomatous lesions from cattle naturally infected with Mycobacterium bovis. For this purpose, we assessed pro-inflammatory and anti-inflamm ... -
The intranasal vaccination of pregnant dams with Intimin and EspBconfers protection in neonatal mice from Escherichia coli (EHEC)O157:H7 infection
Rabinovitz, Bettina Carol; Larzabal, Mariano; Vilte, Daniel Alejandro; Cataldi, Angel Adrian; Mercado, Elsa Cristina (2016-05)Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is responsible for intestinal disease and hemolytic uremic syndrome (HUS), a serious systemic complication which particularly affects children. In this study, we evaluated ... -
Neutralisation of virulence activity of enterohemorrhagic Escherichia coli O157:H7 in vitro through hyperimmune bovine colostrum
Girón, Daniel; Marques Da Silva, Wanderson; Vilte, Daniel Alejandro; Smith, Libia Yael; Casabonne, Maria Carolina; Maldonado May, Veronica; Cataldi, Angel Adrian; Ibarra, Cristina Adriana; Larzabal, Mariano; Sacerdoti, Flavia (Wiley, 2025-07)Background, Context or Rationale Enterohemorrhagic Escherichia coli (EHEC) O157:H7 infection in humans may cause bloody diarrhoea, haemorrhagic colitis and haemolytic uremic syndrome (HUS). Cattle are the main reservoir ... -
Novel Effector Protein EspY3 of Type III Secretion System from Enterohemorrhagic Escherichia coli Is Localized in Actin Pedestals
Larzabal, Mariano; Marques Da Silva, Wanderson; Riviere, Nahuel Agustín; Cataldi, Angel Adrian (MDPI AG, 2018)Enterohemorrhagic Escherichia coli (EHEC) and enteropathogenic Escherichia coli (EPEC) are attaching and effacing (A/E) pathogens, which translocate effector proteins to intestinal enterocytes through a type III secretion ... -
Overexpressed proteins in hypervirulent clade 8 and clade 6 strains of Escherichia coli O157:H7 compared to E. coli O157:H7 EDL933 clade 3 strain
Amigo, Natalia; Qi, Zhang; Amadio, Ariel; Qunjie, Zhang; Marques da Silva, Wanderson; Baiyuan, Cui; Zhongjian, Chen; Larzabal, Mariano; Cataldi, Angel Adrian; Jinlong, Bei (2016)Escherichia coli O157:H7 is responsible for severe diarrhea and hemolytic uremic syndrome (HUS), and predominantly affects children under 5 years. The major virulence traits are Shiga toxins, necessary to develop HUS and ... -
Physiopathological effects of Escherichia coli O157:H7 inoculation in weaned calves fed with colostrum containing antibodies to EspB and Intimin
Rabinovitz, Bettina Carol; Vilte, Daniel Alejandro; Larzabal, Mariano; Abdala, Alejandro Ariel; Galarza, Roxana Ivon; Zotta, Elsa; Ibarra, Cristina E.; Mercado, Elsa Cristina; Cataldi, Angel Adrian (Elsevier, 2014-06-24)Escherichia coli O157:H7 is responsible for severe intestinal disease and hemolytic uremic syndrome (HUS), a serious systemic complication which particularly affects children. Cattle are the primary reservoir for E. coli ... -
Preservation of protective capacity of hyperimmune anti-Stx2 bovine colostrum against enterohemorrhagic Escherichia coli O157:H7 pathogenicity after pasteurization and spray-drying processes
Garimano, Nicolás; Diaz Vergara, Ladislao Iván; Kim, A. D.; Badin, Emiliano Emanuel; Sodero, Sonia; Bernal, Alan Mauro; Gonzalez, Diego; Amaral, María Marta; Lespinard, Alejandro R.; Porporatto, Carina; Montenegro, Mariana A.; Palermo, Marina Sandra; Larzabal, Mariano; Cataldi, Angel Adrian; Ibarra, Cristina Adriana; Sacerdoti, Flavia (Elsevier, 2021-05)Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a major etiologic agent that causes bloody diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome (HUS). Shiga toxin (Stx) is the main virulence factor of EHEC ... -
Secretion systems of pathogenic escherichia coli
Navarro-García, Fernando; Ruiz-Perez, Fernando; Larzabal, Mariano; Cataldi, Angel Adrian (Springer International Publishing, 2016)Protein secretion plays a central role in modulating the interactions of bacteria with their environments. Bacterial ribosomes synthesize up to 8000 different proteins. Almost half of these become integrated in membranes ... -
The role of glucose in the pathology of EHEC O157: H7
Marques Da Silva, Wanderson; Taibo, Catalina Beatriz; Sabio Y Garcia, Julia Veronica; Larzabal, Mariano; Cataldi, Angel Adrian (Cambridge University Press, 2020-04)The pathogen enterohemorrhagic Escherichia coli (EHEC) O157: H7 is responsible for hemorrhagic colitis and hemolytic uremic syndrome in humans [1]. During the colonization process in the gastrointestinal tract, EHEC needs ... -
Type VI secretion system in pathogenic escherichia coli: structure, role in virulence, and acquisition
Navarro-García, Fernando; Ruiz-Perez, Fernando; Cataldi, Angel Adrian; Larzabal, Mariano (Frontiers Media, 2019-08)Bacterial pathogens utilize a myriad of mechanisms to invade mammalian hosts, damage tissue sites, and evade the immune system. One essential strategy of Gram-negative bacteria is the secretion of virulence factors through ...